154978-86-6Relevant articles and documents
Amino sugar derivatives
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, (2008/06/13)
A compound represented by formula (I): STR1 wherein R1 represents --CO--Z1 --N(Z11)--CO--Z2 --H or --CO--Z3 --H, wherein Z1, Z2, and Z3 each represent an alkylene group having from 1 to 20 carbon atoms, a phenylene group, or a combination thereof, and Z11 represents a hydrogen atom, an alkyl group having from 1 to 20 carbon atoms which may be substituted with a phenyl group, a phenyl group which may be substituted with an alkyl group having from 1 to 20 carbon atoms, or an alkylene group having from 1 to 20 carbon atoms which may contain therein a phenylene group; R2 represents --CO--Z4 --N(Z12)--CO--Z5 --H, --CO--Z6 --H or a hydrogen atom, wherein Z4, Z5, and Z6 each have the same meaning as Z1, and Z12 has the same meaning as Z11 ; Q1 and Q2 each represent a carboxyl group or a phosphonoxy group; Q3 represents a hydrogen atom, a carboxyl group or a phosphonoxy group; m represents 0 or an integer of from 1 to 20; n represents 0 or an integer of from 1 to 20; Y1 represents an alkylene group having from 1 to 10 carbon atoms which may contain one or more substituents selected from --OCOR11 and --NHCOR12, wherein R11 represents --Z13 or --Z7 --N (Z14)--CO--Z8 --H (wherein Z7 and Z8 each have the same meaning as Z1, and Z13 and Z14 each have the same meaning as Z11) and R12 represents --Z15 or --Z9 --N(Z16)--CO--Z10 --H (wherein Z9 and Z10 each have the same meaning as Z1, and Z15 and Z16 each have the same meaning as Z11), and a salt thereof. The compound inhibits TNF derivation by endotoxin and is therefore useful for the treatment of multiorganic insufficiencies.