1550-09-0

Basic information

• Product Name: 1-Chloro-6-fluorohexane
• Synonyms: 1-Chloro-6-fluorohexane;1-fluoro-6-chlorohexane
• CAS NO: 1550-09-0
• Molecular Formula: C₆H₁₂ClF
• Molecular Weight: 138.6109
• Mol File: 1550-09-0.mol

Chemical Properties

• Boiling Point: 160°C (estimate)
• Flash Point: 43.8°C
• Appearance: /
• Density: 1.0150
• Vapor Pressure: 4.29mmHg at 25°C
• Refractive Index: 1.4168
• CAS DataBase Reference: 1-Chloro-6-fluorohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-6-fluorohexane(1550-09-0)
• EPA Substance Registry System: 1-Chloro-6-fluorohexane(1550-09-0)

Safety Data

• Hazardous Substances Data: 1550-09-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1-Chloro-6-fluorohexane is used as a chemical intermediate for the production of various organic compounds. Its unique combination of halogen atoms allows it to participate in a range of chemical reactions, facilitating the creation of new molecules with specific properties for different applications.
Used in Solvent Applications:
As a solvent, 1-Chloro-6-fluorohexane is utilized in the dissolution of a variety of substances, particularly those that are otherwise difficult to dissolve in more common solvents. Its solvent properties are leveraged in industrial processes to facilitate reactions or to extract components from mixtures.
Used in Industrial Processes:
1-Chloro-6-fluorohexane is employed in certain specialized industrial applications where its specific chemical properties are advantageous. Its use may be dictated by the need for a substance that can withstand certain conditions or react in a particular way to achieve desired outcomes in manufacturing processes.
Safety Considerations:
It is crucial to handle 1-Chloro-6-fluorohexane with care due to its potential to cause skin and eye irritation. Additionally, inhalation of its vapors may lead to harmful health effects, necessitating proper safety measures during its use in any application.

InChI:InChI=1/C6H12ClF/c7-5-3-1-2-4-6-8/h1-6H2

Upstream product

• 373-32-0 6-fluoro-hexan-1-ol 
• 2163-00-0 1,6-dichlorohexane 
• 4779-64-0 2-(6-chloro-hexyl)-1,1-diphenyl-isourea; hydrofluoride 
• 2009-83-8 6-chloro-1-hexanol 
• 71042-21-2 4-methylbenzenesulfonic acid 6-chlorohexyl ester 
• 1361022-62-9 2-(6-chlorohexyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 928-89-2 6-chlorohexene 

Downstream Products

• 334-28-1 7-fluoro-heptanoic acid 
• 408-27-5 8-fluoro-octan-1-ol 
• 373-30-8 1-fluoro-6-iodohexane 
• 459-95-0 7-fluoro-heptanoic acid ethyl ester 
• 408-15-1 8-fluoro-oct-1-yne 
• 3109-58-8 16-fluorohexadecanoic acid 

Relevant articles and documents

Nickel-Catalyzed Dimerization and Alkylarylation of 1,3-Dienes with Alkyl Fluorides and Aryl Grignard Reagents

In the presence of a nickel catalyst, 1,3-butadiene undergoes selective dimerization and alkylarylation with alkyl fluorides and aryl Grignard reagents to give 1,6-octadienes with alkyl and aryl groups at the 3- and 8-positions, respectively, by the consecutive formation of three carbon-carbon bonds. The formation of an anionic nickel complex plays an important role in forming C-C bonds with alkyl fluorides.

Silver-catalyzed radical fluorination of alkylboronates in aqueous solution

We report herein an efficient and general method for the deboronofluorination of alkylboronates. Thus, with the catalysis of AgNO3, the reactions of various alkylboronic acids or their pinacol esters with Selectfluor reagent in acidic aqueous solution afforded the corresponding alkyl fluorides under mild conditions. A broad substrate scope and wide functional group compatibility were observed. A radical mechanism is proposed for this site-specific fluorination.

A useful conversion of alcohols to alkyl fluorides

A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120-125°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.

Approaches towards the synthesis of fluoro(cyclo)alkylamines

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

FLUORINATION OF HALOGENO ALCOHOLS WITH 1,1,2,3,3,3-HEXAFLUOROPROPYL DIETHYLAMINE

Fluorination of halogeno alcohols with 1,1,2,3,3,3-hexafluoropropyl diethylamine (PPDA) was investigated. 2-Bromo-1-fluorobutane was obtained from the reaction of PPDA and 2-bromo-1-butanol (yield 50percent).Similar results were obtained from other alipha