1550008-55-3

Basic information

• Product Name: ML264
• Synonyms: ML264;(2E)-3-(3-Chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-2-propenamide
• CAS NO: 1550008-55-3
• Molecular Formula: C17H21ClN2O4S
• Molecular Weight: 384.87764
• EINECS: -0
• Mol File: 1550008-55-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 701.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.84±0.46(Predicted)
• CAS DataBase Reference: ML264(CAS DataBase Reference)
• NIST Chemistry Reference: ML264(1550008-55-3)
• EPA Substance Registry System: ML264(1550008-55-3)

Safety Data

• Hazardous Substances Data: 1550008-55-3(Hazardous Substances Data)

Usage

Uses

ML264 is a inhibitor of Krüppel-like Factor Five (KLF5).

Upstream product

• 1866-38-2 m-Chlorocinnamic acid 
• 1268991-10-1 4-(methylamino)tetrahydro-2H-thiopyran-1,1-dioxide hydrochloride 

Relevant articles and documents

KLF5 MODULATORS

The invention provides potent inhibitors of small molecule inhibitors of Krüppel-like factor 5 (KLF5) expression. Compounds of the invention are small molecule inhibitors of KLF5 expression which can be effective delay or prevent colon cancer onset, halt growth of existing tumors, and/or decrease reoccurrence. The compounds can be effective vs. many tumor types whose progression is in part mediated by KLF5, including colorectal cancers. Lowering KLF5 levels with an inhibitor of this invention may also impact other disease states, including diabetes, obesity, lipid homeostasis, cardiovascular disease, and arthritis.