1550175-13-7Relevant academic research and scientific papers
As Hedgehog signal transduction pyrimidine amines and pyridine amine inhibitors
-
Paragraph 0242; 0244; 0249; 0250; 0765-0769, (2019/06/26)
The invention relates to pyrimidinamine and pyridinamine Hedgehog signal conduction inhibitors. The inhibitors are compounds with the structure represented by formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to a medicinal use of the above compounds as hedgehog signal conduction inhibitors.
Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway
Xin, Minhang,Wen, Jun,Tang, Feng,Tu, Chongxing,Huang, Wei,Shen, Han,Zhao, Xinge,Cheng, Lingfei,Wang, Mengyu,Zhang, Liandi
, p. 983 - 988 (2014/02/14)
A novel series of hedgehog signaling pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
