1550177-52-0Relevant academic research and scientific papers
Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway
Xin, Minhang,Wen, Jun,Tang, Feng,Tu, Chongxing,Huang, Wei,Shen, Han,Zhao, Xinge,Cheng, Lingfei,Wang, Mengyu,Zhang, Liandi
, p. 983 - 988 (2014/02/14)
A novel series of hedgehog signaling pathway inhibitors has been designed based on the 4-(2-pyrimidinylamino) benzamides scaffold. The synthesis and SAR of these compounds are described. Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
