155021-30-0Relevant articles and documents
Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin
Radi, Abd-Elgawad,Eissa, Shimaa
, p. 417 - 421 (2010)
The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M-1, respectively. The phase solubility profile, based on the spectrophotometric absorbance's variations, was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with β-CD with a stability constant value, KS, of 846 M-1.