155023-25-9Relevant academic research and scientific papers
A novel and versatile silicon-derived linkage agent, 4-[1-hydroxy-2-(trimethylsilyl)ethyl]benzoic acid, compatible with the Fmoc/t-Bu strategy for solid-phase synthesis of C-terminal peptide acids
Chao, Hann-Guang,Bernatowicz, Michael S.,Reiss, Paul D.,Klimas, Clifford E.,Matsueda, Gary R.
, p. 1746 - 1752 (2007/10/02)
Tryptophan alkylation by resin-derived carbocations and formation of diketopiperazine are two major yield reducing side reactions observed in Fmoc/t-Bu based solid-phase peptide synthesis. With the development of a versatile silicon-based linkage agent, "
