155030-65-2Relevant academic research and scientific papers
Semisynthetic routes to PF1022H - A precursor for new derivatives of the anthelmintic cyclooctadepsipeptide PF1022A
Sivanathan, Sivatharushan,K?rber, Florian,Scherkenbeck, Jürgen
, p. 873 - 876 (2016)
The cyclooctadepsipeptide PF1022A and its semisynthetic, commercial analogue emodepside show excellent anthelmintic properties. Bis-hydroxy PF1022 (PF1022H), a minor fermentative side-product represents an interesting precursor for new PF1022 related anth
METHODS FOR PRODUCTION OF PF1022A DERIVATIVES AND FLOW PLATFORMS USEFUL FOR THE SAME
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Page/Page column 27; 28, (2019/03/12)
Provided herein are improved methods of producing a derivative of PF1022A, for example a compound of Formula I: Formula I wherein R1 and R2 are each independently hydrogen or nitro, and at least one of R1 and R2
Structure-activity relationship of anthelmintic cyclooctadepsipeptides
Ohyama, Makoto,Okada, Yumiko,Takahashi, Masaaki,Sakanaka, Osamu,Matsumoto, Maki,Atsumi, Kunio
scheme or table, p. 1354 - 1363 (2011/10/13)
The relationship between cyclooctadepsipeptides and their anthelmintic efficacy was examined by converting the natural products, PF1022A, PF1022E and PF1022H. Some analoguessubstituted at the para position of the phenyllactate moiety showed higher or equivalent activity against the parasitic nematode, Ascaridia galli in chicken when compared with the parent compounds. It is suggested that lipophilicity and the polar surface area, in addition to structural requirements of the derivatives, influenced the anthelmintic efficacyin vivo.
