155064-25-8

Basic information

• Product Name: 3 5-DI-TERT-BUTYLPHENYL TRIFLUOROMETHAN&
• Synonyms: 3 5-DI-TERT-BUTYLPHENYL TRIFLUOROMETHAN&
• CAS NO: 155064-25-8
• Molecular Formula: C₁₅H₂₁F₃O₃S
• Molecular Weight: 338.39
• Product Categories: Organic Building Blocks;Organic Triflates;Sulfur Compounds
• Mol File: 155064-25-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 24-29 °C(lit.)
• Boiling Point: 327.2±42.0 °C(Predicted)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.190±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3 5-DI-TERT-BUTYLPHENYL TRIFLUOROMETHAN&(CAS DataBase Reference)
• NIST Chemistry Reference: 3 5-DI-TERT-BUTYLPHENYL TRIFLUOROMETHAN&(155064-25-8)
• EPA Substance Registry System: 3 5-DI-TERT-BUTYLPHENYL TRIFLUOROMETHAN&(155064-25-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 155064-25-8(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 1138-52-9 3,5-Di-tert-butylphenol 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 

Downstream Products

• 1119083-61-2 2-(3,5-di-tert-butylphenyl)thiophene 
• 5723-93-3 1-phenyl-3,5-bis(1,1-dimethylethyl)benzene 
• 1577233-07-8 1,3-di-tert-butyl-5-(difluoromethyl)benzene 
• 269086-11-5 4,5-bis-[4,5-bis-(3,5-di-tert-butyl-phenylethynyl)-2-methoxy-phenylethynyl]-2-methoxy-phenol 
• 518344-32-6 1,2-Bis-(3,5-di-tert-butyl-phenylethynyl)-4-ethynyl-5-methoxy-benzene 
• 288387-68-8 4,5-di(3',5'-di-tert-butylphenylethynyl)-2-methoxyphenyl trifluoromethanesulfonate 
• 36720-94-2 1,3-di-tert-butyl-5-ethynylbenzene 
• 823192-21-8 (2E,4E,6Z,8E)-9-(3,5-Di-tert-butyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester 
• 823192-20-7 (2Z,4E)-5-(3,5-Di-tert-butyl-phenyl)-3-methyl-penta-2,4-dienal 
• 916503-45-2 4,9-bis{[3,5-bis(1,1-dimethylethyl)phenyl]oxy}-2,7-bis{4-[(1,1-dimethylethyl)sulfanyl]phenyl}benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone 
• 17610-00-3 3,5-Di-tert-butylbenzaldehyde 
• 1138-52-9 3,5-Di-tert-butylphenol 
• 151417-34-4 [[3,5-bis(1,1-dimethylethyl)phenyl]ethynyl]trimethylsilane 
• 269086-10-4 4,5-di(3',5'-di-tert-butylphenylethynyl)-2-methoxyphenol 

Relevant articles and documents

Transition-Metal-Free C-C, C-O, and C-N Cross-Couplings Enabled by Light

Transition-metal-catalyzed cross-couplings to construct C-C, C-O, and C-N bonds have revolutionized chemical science. Despite great achievements, these metal catalysts also raise certain issues including their high cost, requirement of specialized ligands, sensitivity to air and moisture, and so-called "transition-metal-residue issue". Complementary strategy, which does not rely on the well-established oxidative addition, transmetalation, and reductive elimination mechanistic paradigm, would potentially eliminate all of these metal-related issues. Herein, we show that aryl triflates can be coupled with potassium aryl trifluoroborates, aliphatic alcohols, and nitriles without the assistance of metal catalysts empowered by photoenergy. Control experiments reveal that among all common aryl electrophiles only aryl triflates are competent in these couplings whereas aryl iodides and bromides cannot serve as the coupling partners. DFT calculation reveals that once converted to the aryl radical cation, aryl triflate would be more favorable to ipso substitution. Fluorescence spectroscopy and cyclic voltammetry investigations suggest that the interaction between excited acetone and aryl triflate is essential to these couplings. The results in this report are anticipated to provide new opportunities to perform cross-couplings.

9-cis-Retinoic acid analogues with bulky hydrophobic rings: New RXR-selective agonists

Stille cross-coupling of aryltriflates 10 and dienylstannane 11, oxidation and Horner-Wadsworth-Emmons reaction afforded stereoselectively retinoates 15. Saponification provided the carboxylic acids 8a and 8b, retinoids that incorporate a bulky hydrophobic ring while preserving the 9-cis-geometry of the parent system. In contrast to the pan-RAR/RXR agonistic profile of the lower homologue of 8a, compound 7 (LG100567), retinoids 8 showed selective binding and transactivation of RXR, devoid of significant RAR activation. In PLB985 leukemia cells that require RXR agonists for differentiation compounds 8 induced maturation in the presence of the RAR-selective pan-agonist TTNPB; this effect was blocked by an RXR-selective antagonist.