155071-29-7Relevant articles and documents
Asymmetric Nitrogen-containing dimer from aerial parts of mercurialis leiocarpa and its synthesis by mimicking generation process through radical intermediates
Ino, Sayaka,Kondo, Yuto,Matsuda, Hisashi,Nakamura, Seikou,Nakashima, Souichi,Yamashita, Haruka,Yamashita, Masayuki
, p. 520 - 525 (2020/07/31)
An asymmetric nitrogen-containing dimer, leiocarpanine A, was isolated from the aerial part of Mercurialis leiocarpa as a new compound. The new generation process of leiocarpanine A was estimated and a concise synthesis of leiocarpanine A could be detailed based on mimicking the generation process through the radical intermediates. In general, a lot of reaction step and organic reagents are required for the synthesis of asymmetric nitrogen-containing dimers. However, our new synthesis method enables a concise synthesis of asymmetric nitrogen-containing dimers through radical intermediates by only liquid-separation. This synthetic method provides a rapid and concise pathway to construct a library of nitrogen-containing dimers that might be useful for drug discovery. In addition, it is useful to elucidate the generation process of leiocarpanine A.
