155088-20-3Relevant articles and documents
Total Synthesis of Pukeleimide A, a 5-Ylidenepyrrol-2(5H)-on e from Blue Green Algae
James, Gwyn D.,Mills, Stuart D.,Pattenden, Gerald
, p. 2581 - 2584 (2007/10/02)
A total synthesis of pukeleimide A 5, a member of a rare family of naturally occuring 5-ylidenepyrrol-2(5H)-ones produced by the marine blue alga Lyngbya majuscula, is described.The synthesis is based on elaboration of the ylidenepyrrolone 11a from the maleimide 13a by a regio- and stereo-selective Wittig reaction with ethoxycarbonylmethylene(triphenyl)phosphorane, followed by conversion of 11a into the amide 25, and oxidation of 25 with selenium dioxide.