155092-08-3

Upstream product

• 155091-91-1 1-benzyl-5-butyl-2-hydroxymethylimidazole 
• 155091-90-0 1-benzyl-5-butylimidazole 
• 155091-93-3 4⁽⁵⁾-butyl-2-hydroxymethylimidazole 
• 155092-17-4 1-acetyl-4-butylimidazole 
• 148674-47-9 4⁽⁵⁾-n-butylimidazole-2-carboxaldehyde 
• 146953-86-8 4-n-Butyl-imidazole 
• 24764-98-5 2-bromohexanal 
• 155092-07-2 1-<<2'-<(N-triphenylmethyl)tetrazol-5-yl>biphenyl-4-yl>methyl>-4-butylimidazole-2-carboxaldehyde 

Relevant academic research and scientific papers

Imidazole based non-peptide angiotensin II receptor antagonists. Investigation of the effects of the orientation of the imidazole ring on biological activity

Non-peptide angiotensin II receptor antagonists related to losartan (DuP 753, CAS 114798-26-4) were prepared and evaluated for antagonist activity in the rat isolated uterus assay. The synthetic strategy concentrated on changes in the orientation of the imidazole ring relative to the substituents, which were maintained in a similar pattern to that found in losartan. The results indicate that biological activity of such antagonists shows little dependence on the orientation of the imidazole ring, but that the spacing of the substituents is of primary importance.