155092-77-6

Basic information

• Product Name: Tetrazolo[1,5-c]quinazoline, 5-ethoxy- (9CI)
• Synonyms: Tetrazolo[1,5-c]quinazoline, 5-ethoxy- (9CI)
• CAS NO: 155092-77-6
• Molecular Formula: C10H9N5O
• Molecular Weight: 215.21136
• Product Categories: ETHOXY
• Mol File: 155092-77-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tetrazolo[1,5-c]quinazoline, 5-ethoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrazolo[1,5-c]quinazoline, 5-ethoxy- (9CI)(155092-77-6)
• EPA Substance Registry System: Tetrazolo[1,5-c]quinazoline, 5-ethoxy- (9CI)(155092-77-6)

Safety Data

• Hazardous Substances Data: 155092-77-6(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 607-68-1 2,4-dichloroquinazoline 
• 858235-57-1 2-chloro-4-[(4-chlorophenyl)thio]quinazoline 

Relevant articles and documents

Application of Azide-Tetrazole Tautomerism and Arylsulfanyl Group Dance in the Synthesis of Thiosubstituted Tetrazoloquinazolines

Nucleophilic aromatic substitution reaction between 4-aryl-thio-2-chloroquinazolines and NaN 3takes place with an unusual sulfanyl group dance and leads to the formation of 5-(arylthio)tetrazolo[1,5- c ]-quinazolines, which do not form the azide tautomer and do not undergo CuAAC reactions with alkynes. On the other hand, 5-azidotetrazolo[1,5- a ]quinazoline (formally described as 2,4-diazidoquinazoline) undergoes regioselective nucleophilic aromatic substitution with thiols at C5 and forms 5-(alkyl/arylthio)tetrazolo[1,5- a ]quinazolines, the structure of which has been proved by X-ray crystallography. The latter exist in tautomeric equilibrium with their 2-azidoquinazoline form, which provides possibility for copper-catalyzed azide-alkyne 1,3-dipolar cyclo-addition reaction, leading to the 4-alkyl/arylthio-2-(1 H -1,2,3-triazol-1-yl)quinazolines.