155098-65-0

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 

Downstream Products

• 1335151-12-6 methyl 4-(4,4-dihydroperoxycyclohexyl)benzoate 
• 137464-98-3 4-(4-oxocyclohexyl)benzoic acid methyl ester 
• 14472-80-1 4-(4-chlorophenyl)cyclohexan-1-one 
• 1374338-80-3 1-{6-[4'-(4,4-difluorocyclohexyl)-4-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

A series of aryl carboxamide and benzylamino dispiro 1,2,4,5-tetraoxane analogues have been designed and synthesized in a short synthetic sequence from readily available starting materials. From this series of endoperoxides, molecules with in vitro IC50s versus Plasmodium falciparum (3D7) as low as 0.84 nM were identified. Based on an assessment of blood stability and in vitro microsomal stability, N205 (10a) was selected for rodent pharmacokinetic and in vivo antimalarial efficacy studies in the mouse Plasmodium berghei and Plasmodium falciparum Pf3D70087/N9 severe combined immunodeficiency (SCID) mouse models. The results indicate that the 4-benzylamino derivatives have excellent profiles with a representative of this series, N205, an excellent starting point for further lead optimization studies.

Method for synthesizing 4-(4-chlorphenyl) cyclohexanone

The invention relates to the filed of organic synthesis, and discloses a method for synthesizing chemical intermediate 4-(4-chlorphenyl) cyclohexanone. The method includes the steps that (1) 4-(4-hydroxy-phenyl) cyclohexanone and pyridine are mixed in an

SOLUBLE GUANYLATE CYCLASE ACTIVATORS

This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.