155143-15-0

Upstream product

• 75-66-1 2-methylpropan-2-thiol 
• 168018-34-6 ethyl 1-(4-chlorobenzyl)-3-(t-butylthio)-5-methoxyindole-2-carboxylate 
• 168018-33-5 ethyl 5-methoxy-3-(t-butylthio)indole-2-carboxylate 
• 141863-12-9 ethyl 3-tert-butylthio-2-oxo-propionate 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 

Downstream Products

• 168018-39-1 2-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethoxy]-isoindole-1,3-dione 
• 168018-42-6 2-[(E)-3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethoxyimino]-propionic acid methyl ester 
• 168018-37-9 3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indole-2-carboxylic acid 
• 168018-40-4 O-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-ylmethyl]-hydroxylamine 
• 168018-38-0 [3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-methanol 

Relevant academic research and scientific papers

Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors

A series of substituted indolylalkoxyiminoalkylcarboxylates were found to be potent leukotriene biosynthesis inhibitors. The structure-activity relationships were investigated. Representative potent inhibitors identified were the quinolyl 3a (A-86885) and pyridyl 3b (A-86886) congeners with in vitro IC50s of 21 and 9 nM and in vivo leukotriene inhibition in the rat with oral ED50s of 0.9 and 1.7 mg/kg, respectively.

INDOLE IMINOOXY DERIVATIVES WHICH INHIBIT LEUKOTRIENE BIOSYNTHESIS

Compounds of the structure where A1 is alkylene or cycloalkylene; A2 is a valence bond, alkylene, or cycloalkylene; R1 is selected from hydrogen, alkylthio, optionally substituted phenylthio, optionally substituted phenylalkylthio, optionally substituted