1551544-01-4Relevant academic research and scientific papers
A concise synthesis of carolacton
Hallside, Michal S.,Brzozowski, Richard S.,Wuest, William M.,Phillips, Andrew J.
, p. 1148 - 1151 (2014/03/21)
A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton's structure-function relationships are warranted.
