15516-60-6

Basic information

• Product Name: 5-Nitroso-salicylate
• Synonyms: 5-Nitroso-salicylate
• CAS NO: 15516-60-6
• Molecular Formula: C₇H₅NO₄
• Molecular Weight: 167.12
• Mol File: 15516-60-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 402.7°Cat760mmHg
• Flash Point: 197.3°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 3.31E-07mmHg at 25°C
• Refractive Index: 1.617
• PKA: 2.26±0.10(Predicted)
• CAS DataBase Reference: 5-Nitroso-salicylate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitroso-salicylate(15516-60-6)
• EPA Substance Registry System: 5-Nitroso-salicylate(15516-60-6)

Safety Data

• Hazardous Substances Data: 15516-60-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H5NO4/c9-6-2-1-4(8-12)3-5(6)7(10)11/h1-3,9H,(H,10,11)

Upstream product

• 41085-71-6 bromamine T 

Downstream Products

• 89-57-6 5-Aminosalicylic Acid 
• 2835-05-4 2-amino-5-hydroxy-benzenesulfonic acid 
• 202117-16-6 2-Hydroxy-5-nitroso-benzoesaeure-methylester 

Relevant articles and documents

Mechanistic chemistry of oxidation of balsalazide with acidic chloramine-T and bromamine-T: A comparative spectrophotometric kinetic study

Balsalazide (BSZ) belongs to a class of non-steroidal anti-inflammatory drugs. Kinetics and mechanism of oxidation of BSZ with sodium N-halo-p-toluenesulfonamides viz., chloramine-T(CAT) and bromamine-T(BAT) in HClO4 medium have been spectrophotometrically investigated (λ max = λambda -{max } =$ 357nm) at 303 K. Under comparable experimental conditions, reactions with both the oxidants follow a first-order dependence of rate on [BSZ] and fractional-order dependence on each [oxidant] and [HClO4]. Activation parameters and reaction constants have been computed. 2-hydroxy-5-nitroso-benzoic acid and 3-(4-nitroso-benzoylamino)-propionic acid are identified as the oxidation products of BSZ with both CAT and BAT. The rate of oxidation of BSZ is about five-fold faster with BAT than with CAT. Plausible mechanism and related rate law have been deduced for the observed kinetics. [Figure not available: see fulltext.]