1551635-06-3Relevant academic research and scientific papers
Synthesis, structural characterization and cytotoxicity of bimetallic chlorogold(I) phosphine complexes employing functionalized phosphinoferrocene carboxamides
Schulz, Ji?í,Tauchman, Ji?í,Císa?ová, Ivana,Riedel, Tina,Dyson, Paul J.,?těpni?ka, Petr
, p. 604 - 609 (2014)
Gold(I) phosphine complexes of the general formula [AuCl(Ph 2PfcCONHY-κP)], where Y is CH2CO2Me (7), CH2CONH2 (8), CH2CH2OH (9), CH(CH2OH)2 (10), C(CH2OH)3 (11), and CH2SO3(HNEt3) (12), and fc is ferrocene-1, 10-diyl, were prepared from [AuCl(tht)] (tht = tetrahydrothiophene) and the appropriate phosphinoferrocene carboxamides (1-6). The compounds were characterized by spectroscopic and analytical methods, and the molecular structures of 7 and 9 were determined by single-crystal X-ray crystallography. Complexes 7-12 exerted antiproliferative activity against the human ovarian cancer cells in vitro. The IC50 values ranged ca. 0.3-3.7 μM for the A2780 cell line, and 3.1-20 μM for the cisplatin resistant cell line A2780R, with complex 7 being the most cytotoxic against both cell types. IC 50 values for the non-tumorigenic human embryonic kidney (HEK) cells, serving as a measure of a general toxicity, were found in roughly similar ranges, i.e. 0.9-6.8 μM.
