155185-25-4

Upstream product

• 164905-37-7 [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 

Downstream Products

• 164905-43-5 [(2,4-Dinitro-phenyl)-hydroxy-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-44-6 [(2,6-Dichloro-phenyl)-hydroxy-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-42-4 [Hydroxy-(2-nitro-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-36-6 [(4-Dimethylamino-phenyl)-hydroxy-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-40-2 [(4-Cyano-phenyl)-hydroxy-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-37-7 [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-38-8 α-Hydroxybenzylphosphonsaeure-bis-(5'-O-2',3'-didesoxythymidin)ester 
• 164905-41-3 [Hydroxy-(4-nitro-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-39-9 [(4-Chloro-phenyl)-hydroxy-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 164905-35-5 (Hydroxy-p-tolyl-methyl)-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 

Relevant academic research and scientific papers

Homo dinucleoside-α-hydroxyphosphonate diesters as prodrugs of the antiviral nucleoside analogues 2',3'-dideoxythymidine and 3'-azido-2',3'- dideoxythymidine

The synthesis of a new prodrug system for antiviral nucleosides AZT (1) and ddT (2) based on α-hydroxyhenzylphosphonates 3 is described. 3 hydrolyze via different mechanisms yielding the H-phosphonate monoesters 4 or nucleoside monophosphates 5, respectively, 3 were more lipophilic than 1, 2 and showed marked activity against HIV-1/2.