155211-09-9

Basic information

• Product Name: (2R,3S)-3-Benzenesulfonyl-2-(tetrahydro-pyran-2-yloxymethyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
• Synonyms: (2R,3S)-3-Benzenesulfonyl-2-(tetrahydro-pyran-2-yloxymethyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
• CAS NO: 155211-09-9
• Molecular Weight: 497.61
• Mol File: 155211-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-Benzenesulfonyl-2-(tetrahydro-pyran-2-yloxymethyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-Benzenesulfonyl-2-(tetrahydro-pyran-2-yloxymethyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester(155211-09-9)
• EPA Substance Registry System: (2R,3S)-3-Benzenesulfonyl-2-(tetrahydro-pyran-2-yloxymethyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester(155211-09-9)

Safety Data

• Hazardous Substances Data: 155211-09-9(Hazardous Substances Data)

Upstream product

• 116611-45-1 (2R)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane 
• 541-41-3 chloroformic acid ethyl ester 
• 187409-26-3 (2R)-1-(tert-butyloxycarbonyl)-2-<<(2-tetrahydropyranyl)oxy>methyl>-3-(phenylsulfonyl)pyrrolidine 

Relevant articles and documents

Enantioselective synthesis of (2S,3S)- and (2R,3R)-pyrrolidine-2,3-dicarboxylic acids: Conformationally constrained (S)- and (R)-aspartic acid analogues

The title compounds were prepared from the key intermediate 2 and its enantiomer at C2, derived from chiral synthons 1-(R) and 1- (S), respectively, by ethoxycarbonylation, desulfonylation and conversion to carboxylic acid.