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15522-23-3

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15522-23-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 15522-23-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,2 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 15522-23:
(7*1)+(6*5)+(5*5)+(4*2)+(3*2)+(2*2)+(1*3)=83
83 % 10 = 3
So 15522-23-3 is a valid CAS Registry Number.

15522-23-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-amino-2,5-dimethoxyphenyl)-phenylmethanone

1.2 Other means of identification

Product number -
Other names [PtCl(diethylenetriamine)](1+)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15522-23-3 SDS

15522-23-3Relevant articles and documents

Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand

Monroe, Jerry D.,Hruska, Heidi L.,Ruggles, Hannah K.,Williams, Kevin M.,Smith, Michael E.

, (2019)

Unlike cisplatin, which forms bifunctional DNA adducts, monofunctional platinum(II) complexes bind only one strand of DNA and might target cancer without causing auditory side-effects associated with cisplatin treatment. We synthesized the monofunctional triamine-ligated platinum(II) complexes, Pt(diethylenetriamine)Cl, [Pt(dien)Cl]+, and Pt(N,N-diethyl-diethylenetriamine)Cl, [Pt(Et2dien)Cl]+, and the monofunctional heterocyclic-ligated platinum(II) complexes, pyriplatin and phenanthriplatin, and compared their 5’-GMP binding rates, cellular compartmental distribution and cellular viability effects. A zebrafish inner ear model was used to determine if the monofunctional complexes and cisplatin caused hearing threshold shifts and reduced auditory hair cell density. The four monofunctional complexes had varied relative GMP binding rates, but similar cytosolic and nuclear compartmental uptake in three cancer cell lines (A549, Caco2, HTB16) and a control cell line (IMR90). Phenanthriplatin had the strongest effect against cellular viability, comparable to cisplatin, followed by [Pt(Et2dien)Cl]+, pyriplatin and [Pt(dien)Cl]+. Phenanthriplatin also produced the highest hearing threshold shifts followed by [Pt(dien)Cl]+, [Pt(Et2dien)Cl]+, cisplatin and pyriplatin. Hair cell counts taken from four regions of the zebrafish saccule showed that cisplatin significantly reduced hair cell density in three regions and phenanthriplatin in only one region, with the other complexes having no significant effect. Utricular hair cell density was not reduced by any of the compounds. Our results suggest that placing greater steric hindrance cis to one side of the platinum coordinating center in monofunctional complexes promotes efficient targeting of the nuclear compartment and guanosine residues, and may be responsible for reducing cancer cell viability. Also, the monofunctional compounds caused hearing threshold shifts with minimal effect on hair cell density, which suggests that they may affect different pathways than cisplatin.

Alcock, Roland M.,Hartley, Frank R.,Rogers, David E.

, (1978)

Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl2·2H2O

Kosovi?, Milica,Jovanovi?, Sne?ana,Bogdanovi?, Goran A.,Giester, Gerald,Ja?imovi?, ?eljko,Bugar?i?, ?ivadin D.,Petrovi?, Biljana

, p. 2819 - 2831 (2016)

Substitution reactions of [Pt(terpy)Cl]+ (terpy?=?2,2′;6′,2′′-terpyridine), [Pt(bpma)Cl]+ (bpma?=?bis(2-pyridylmethyl)amine), [Pt(dien)Cl]+ (dien?=?diethylenetriamine or 1,5-diamino-3-azapentane) and [Pt(tpdm)Cl]+/su

Kinetics of the Displacement of Chloroacetate Ion from cis-Bis(chloroacetato)-bis(isopropylamine)platinum(II) and the (Chloroacetato)(1,5-diamino-3-azapentane)platinum(II) Cation

Canovese, Luciano,Tobe, Martin L.,Annibale, Giuliano,Cattalini, lucio

, p. 1107 - 1114 (2007/10/02)

The displacement of ClCH2CO2- from cis-iNH2)2(ClCH2CO2)2> and + (dien=1,5-diamino-3-azapentane) by solvent, Cl-, Br-, and SCN- has been studied in aqueous solution at 25.0 deg C.The reactions are catalysed by acid by way of a pre-equilibrium protonation of the carboxylate ligand.In the absence of added acid the cationic monocarboxylato complex exhibits a normal nucleophilic discrimination power, comparable to that of the corresponding chloro complex and the nucleophile-independent pathway makes only a small contribution to the consumption of the substrate.In the uncatalysed reactions of the bis(carboxylato) complex, the nucleophile-independent pathway dominates the substitution by the weak nucleophile, Cl-, and a relatively strong nucleophile, such as SCN-, is required to make the direct substitution pathway important.The unusually large contribution from the nucleophile-independent pathway is discussed.

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