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155221-41-3

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155221-41-3 Usage

Structure

Nitrogen-containing heterocyclic compound derived from benzimidazole

Explanation

The compound is a heterocyclic compound, meaning it contains a ring of atoms with at least one nitrogen atom. It is derived from benzimidazole, which is a fused-ring system consisting of a benzene ring and an imidazole ring.

Explanation

The benzene ring in this compound has three methyl (CH3) groups attached to it, which are located at the 1st, 2nd, and 6th positions of the ring.

Explanation

The compound is a solid at room temperature and appears as a white crystalline substance.

Explanation

The melting point is the temperature at which the compound transitions from a solid to a liquid state. In this case, the compound melts at a range of 231-232°C.

Explanation

Due to its structural properties and reactivity, this compound is used as a starting material or intermediate in the synthesis of various pharmaceuticals, dyes, and other organic compounds.

Explanation

The compound's structural properties and reactivity make it a promising candidate for use in the development of new drugs and pharmaceuticals.

Substituents

Three methyl groups attached to different positions on the benzene ring

Physical State

White crystalline solid

Melting Point

231-232°C

Applications

Building block in the synthesis of pharmaceuticals, dyes, and other organic compounds

Potential Applications

Pharmaceutical industry

Check Digit Verification of cas no

The CAS Registry Mumber 155221-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,2,2 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 155221-41:
(8*1)+(7*5)+(6*5)+(5*2)+(4*2)+(3*1)+(2*4)+(1*1)=103
103 % 10 = 3
So 155221-41-3 is a valid CAS Registry Number.

155221-41-3Upstream product

155221-41-3Downstream Products

155221-41-3Relevant articles and documents

Structure-Activity Studies of Benzimidazole-Based DNA-Cleaving Agents. Comparison of Benzimidazole, Pyrrolobenzimidazole, and Tetrahydropyridobenzimidazole Analogues

Skibo, Edward B.,Islam, Imadul,Heileman, Matthew J.,Schulz, William G.

, p. 78 - 92 (2007/10/02)

The synthesis and cytotoxic properties of benzimidazole-based DNA-cleaving agents are presented herein.These agents include pyrrolobenzimidazole (PBI), benzimidazole (BI), and tetrahydropyridobenzimidazole (TPBI) analogues.As a result of these studies, it is concluded that the pyrrolo ring is not necessary for cytotoxicity (PBI is only slightly more cytotoxic than BI) but that homologation of the pyrrolo ring by one carbon results in a system, TPBI, prone to decomposition.Another conclusion is that the 6-aziridinyl derivative of the PBI system is more potent than the 7-aziridinyl derivative.Comparative studies with known antitumor agents revealed that the benzimidazole-based DNA-cleaving agents possess a unique spectrum of activity.Noteworthy observations are the high level of cytotoxicity against melanoma cell lines and the complete absence of activity against leukemia cell lines.The reductive activation and DNA-cleavage properties of the most active analogue (BI-A) are also presented.Reduction of the quinone ring to the hydroquinone results in nucleophile and proton trapping by the aziridinyl group.Documented nucleophiles include water and the oxygen anion of 5'-dAMP.In addition, reduced BI-A reacts with DNA to form a stable adduct, which cleaves at G + A bases upon heating in basic gel-loading solution.

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