155222-86-9

Basic information

• Product Name: 4-[(3-fluorophenyl)acetyl]morpholine
• Synonyms: 4-[(3-fluorophenyl)acetyl]morpholine
• CAS NO: 155222-86-9
• Molecular Formula: C12H14FNO2
• Molecular Weight: 223.2434632
• Mol File: 155222-86-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(3-fluorophenyl)acetyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(3-fluorophenyl)acetyl]morpholine(155222-86-9)
• EPA Substance Registry System: 4-[(3-fluorophenyl)acetyl]morpholine(155222-86-9)

Safety Data

• Hazardous Substances Data: 155222-86-9(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 813414-83-4 1-bromo-2-(meta-fluorophenyl)ethyne 
• 1073-06-9 3-fluorobromobenzene 
• 1121-86-4 1-Fluoro-3-iodobenzene 

Relevant articles and documents

Preparation and Application of Solid, Salt-Stabilized Zinc Amide Enolates with Enhanced Air and Moisture Stability

The treatment of various N-morpholino amides with TMPZnCl?LiCl (TMP=2,2,6,6-tetramethylpiperidyl) and Mg(OPiv)2 in THF at 25 °C provides solid zinc enolates with enhanced air and moisture stability (t1/2 in air: 1–3 h) after solvent evaporation. These enolates undergo Pd- and Cu-catalyzed cross-couplings with (hetero)aryl bromides as well as allylic and benzylic halides. The arylated N-morpholino amides were converted into various ketones by LaCl3?2 LiCl mediated acylation with Grignard reagents. The new, solid enolates were used to prepare a potent anti-breast-cancer drug candidate in six steps and 23 % overall yield.

A Study of the Ferrous Ion-initiated SRN1 Reactions of Halogenoarenes with tert-Butyl Acetate and N-Acylmorpholine Enolates

A detailed preparative study is reported of the ferrous ion-initiated SRN1 reactions of a range of halogenoarenes with the sodium enolates of tert-butyl acetate, n-acetylmorpholine and a number of higher N-acylmorpholines.Smooth and rapid substitution occurs in many cases, and good to excellent yields were obtained of arylacetic esters or acids, arylacetamides and arylalkanamides.The broad scope and limitations of the process have been defined, and the possible role of the ferrous ion is discussed.