1552301-52-6Relevant academic research and scientific papers
Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors
Lin, Songwen,Han, Fangbin,Liu, Peng,Tao, Jing,Zhong, Xuechao,Liu, Xiujie,Yi, Chongqin,Xu, Heng
, p. 790 - 793 (2014/02/14)
Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most intensively studied approaches to cancer therapy. Rational design led to the identification of novel 7-amino-5-methyl-1,6-naph
Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives
Han, Fangbin,Lin, Songwen,Liu, Peng,Tao, Jing,Yi, Chongqin,Xu, Heng
, p. 4538 - 4541 (2015/02/06)
Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway by PI3K/mTOR dual inhibitors provides a promising new approach to the treatment of cancers. In this Letter, we identified structurally novel and
