155250-98-9

Upstream product

• 71565-21-4 (2S,4'R)-(+)-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-1-propanol 
• 936495-17-9 {(2R,3R)-3-[(R)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-oxiranyl}-methanol 
• 155324-96-2 (2S,3S,4S)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentane-1,3-diol 
• 77398-87-9 (2R)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanal 
• 155250-90-1 (E)-(S)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-pent-2-en-1-ol 
• 155433-68-4 ethyl (2E,4S,5R)-5,6-isopropylidenedioxy-4-methyl-2-hexenoate 
• 936573-12-5 (2S,3S,4S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentan-3-ol 
• 936495-04-4 ((2S,3S,4S)-3-Benzyloxy-2-methyl-4-(R)-oxiranyl-pentyloxy)-tert-butyl-diphenyl-silane 
• 936495-03-3 (2R,3R,4S,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexane-1,2-diol 
• 936573-13-6 [(2S,3S,4S)-3-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane 

Downstream Products

• 936495-07-7 (2S,3S,4R,5S)-3,5-Bis-benzyloxy-7-methoxymethoxy-2,4-dimethyl-heptan-1-ol 
• 936495-08-8 C₂₅H₃₅IO₄ 
• 936495-05-5 (3S,4R,5S,6S)-3,5-Bis-benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-4,6-dimethyl-heptan-1-ol 
• 936495-06-6 ((2S,3S,4R,5S)-3,5-Bis-benzyloxy-7-methoxymethoxy-2,4-dimethyl-heptyloxy)-tert-butyl-diphenyl-silane 
• 936573-15-8 (3S,4S,5S,6S)-3-((Z)-(3S,4S,5R,6S)-4,6-Bis-benzyloxy-8-methoxymethoxy-3,5-dimethyl-oct-1-enyl)-4,6-dimethyl-2,8-dioxa-bicyclo[3.2.1]octane 
• 936573-19-2 Acetic acid (1S,2R,3S,4S)-3-acetoxy-6-((3S,4R,5S,6S)-4,6-dimethyl-2,8-dioxa-bicyclo[3.2.1]oct-3-yl)-2,4-dimethyl-1-(2-trityloxy-ethyl)-hexyl ester 

Relevant academic research and scientific papers

Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

Aplyronine A (2), a potent antitumor macrolide was isolated from the sea hare Aplysia kurodai together with the congeners aplyronines B (3) and C (4). The absolute stereostructure of aplyronine A (2) was determined by the instrumental analysis (mainly NMR and MS) and the enantioselective synthesis of the fragments obtained from chemical degradation of aplyronine A (2). The structures of aplyronines B (3) and C (4) were also elucidated. Cytotoxicity and antitumor activity of aplyronine A (2) were evaluated.

Studies on the Stereochemistry of Aplyronine A: Determination of the Stereochemistry of the C21-C34 Fragment

The absolute stereochemistry of the C21-C34 fragment 2 of aplyronine A (1), a potent antitumor substance of marine origin, was determined by the enantioselective synthesis.