155272-03-0

Basic information

• Product Name: (8E)-1,3-diethyl-8-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-7-methyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione
• CAS NO: 155272-03-0
• Molecular Formula: C₁₈H₂₀N₄O₄
• Molecular Weight: 356.3758
• Mol File: 155272-03-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 476.5°C at 760 mmHg
• Flash Point: 242°C
• Density: 1.42g/cm³
• Vapor Pressure: 4.43E-11mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: (8E)-1,3-diethyl-8-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-7-methyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (8E)-1,3-diethyl-8-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-7-methyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione(155272-03-0)
• EPA Substance Registry System: (8E)-1,3-diethyl-8-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-7-methyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione(155272-03-0)

Safety Data

• Hazardous Substances Data: 155272-03-0(Hazardous Substances Data)

Usage

General Description

The chemical "(8E)-1,3-diethyl-8-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-7-methyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione" is a complex organic compound with a purine-based structure. It contains a diethyl group, as well as a cyclohexa-2,5-dien-1-ylidene and a hydroxyl group. This chemical is classified as a purine derivative, and its 3D structure indicates several double bonds and rings. It's important to note that due to its complex structure, this compound likely has a range of biological activities and may be used in a variety of research and pharmaceutical applications.

Upstream product

• 155270-99-8 istradefylline 

Downstream Products

• 160434-48-0 (E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione 

Relevant articles and documents

Preparation method for removing methyl impurities from istradefylline

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a preparation and purification method for removing methyl impurities from istradefylline. Istradefylline is used as a raw material to prepare three high-purity demethylated impurity compounds I, II and III, the method is simple in process, easy to operate, simple in purification and high in yield, the prepared impurities are high in purity, and qualified impurity reference substances can be provided for quality control of istradefylline. The istradefylline impurity reference substance prepared by the invention can provide an important reference basis for monitoring the impurity in the research and development of an istradefylline process, improves the quality monitoring level of istradefylline, and has great significance and practical value for the development of medicinal istradefylline.

Therapeutic agent for Parkinson's disease

Agents for the treatment of Parkinson''s disease contain, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: STR1 in which R 1, R 2 are R 3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R 4 represents cycloalkyl, --(CH 2) n --R 5 (in which R 5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or STR2 in which Y 1 and Y 2 represent independently hydrogen, halogen, or lower alkyl; and Z represents substituted or unsubstituted aryl, STR3 in which R 6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X 1 and X 2 represent independently O or S.