155302-28-6

Basic information

• Product Name: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester;t-Butyl-4-(1H-indol-3-yl)piperidine-1-carboxylate
• CAS NO: 155302-28-6
• Molecular Formula: C₁₈H₂₄N₂O₂
• Molecular Weight: 300.4
• Mol File: 155302-28-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 460.5±38.0 °C(Predicted)
• Appearance: /
• Density: 1.149
• Storage Temp.: 2-8°C
• PKA: 17.06±0.30(Predicted)
• CAS DataBase Reference: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester(155302-28-6)
• EPA Substance Registry System: 4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester(155302-28-6)

Safety Data

• Hazardous Substances Data: 155302-28-6(Hazardous Substances Data)

Usage

General Description

4-(1H-Indol-3-yl)piperidine-1-carboxylic acid tert-butyl ester is a compound with the molecular formula C21H25N3O2. It is a tert-butyl ester derivative of piperidine-1-carboxylic acid, which contains an indole ring. This chemical is commonly used in organic synthesis as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of various biologically active compounds. The tert-butyl ester group in this compound provides stability and protection for the carboxylic acid, making it a useful reagent in organic chemistry.

Upstream product

• 155302-27-5 3-[N-(t-butyloxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-indole 
• 120-72-9 indole 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17403-09-7 3-(4-piperidinyl)-1H-indole 
• 345235-80-5 tert-butyl-4-(5-chloro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 17422-32-1 5-chloro-1H-indole 

Downstream Products

• 1201648-28-3 4-[1-(Toluene-4-sulfonyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 855775-78-9 tert-butyl 4-[1-[4-(methylsulfonyl)benzyl]-1H-indol-3-yl]-1-piperidinecarboxylate 
• 60155-63-7 4-(1H-indol-3-yl)piperidinium chloride 
• 1443248-77-8 4-(1H-indol-3-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide 
• 855775-84-7 C₂₅H₃₀N₂O₂ 
• 855775-21-2 4-(1-(phenylsulfonyl)-1H-indol-3-yl)piperidinium chloride 
• 393508-48-0 4-(1-benzenesulfonyl-1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 17403-09-7 3-(4-piperidinyl)-1H-indole 
• 855775-87-0 tert-butyl 4-[1-[4-(trifluoromethyl)benzoyl]-1H-indol-3-yl]-1-piperidinecarboxylate 
• 855776-16-8 tert-butyl 4-(1-(phenylsulfonyl)-1H-indol-3-yl)piperidine-1-carboxylate 

Relevant articles and documents

HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME

A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt, a solvate, or a solvate of a pharmaceutically acceptable salt thereof, use thereof, and a composition containing the same. The compound is novel in structure and has good STAT5 inhibitory activity.

Substituted heterocyclic compounds and its application on the medicament (by machine translation)

The invention relates to substituted heterocyclic compounds and its application on the medicament, in particular to a novel class of substituted heterocyclic compounds or its isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug, and their method of preparation. The invention also relates to the compounds of the invention pharmaceutical composition, and said compound or pharmaceutical compositions for the treatment5-HT6receptor-related diseases, in particular Alzheimer's disease in the use thereof. (by machine translation)

COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS

The present invention relates to new medicament combinations which contain in addition to one or more PDE4-inhibitors (1) at least one EP4 receptor antagonist (2), as well as the use thereof for the treatment of preferably respiratory complaints such as particularly COPD, chronic sinusitis and asthma. The invention relates in particular to those medicament combinations which contain, in addition to one or more, preferably one, PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R1, R2, R3 and R4 have the meanings given in claim 1, at least one EP4 receptor antagonist (2), the preparation thereof and the use thereof for the treatment of respiratory complaints.