155322-96-6

Basic information

• Product Name: 2,5-Piperazinedione,3-(hydroxymethyl)-6-(1-methylethyl)-,(3R,6S)-(9CI)
• Synonyms: 2,5-Piperazinedione,3-(hydroxymethyl)-6-(1-methylethyl)-,(3R,6S)-(9CI);(3R,6S)-3-(HYDROXYMETHYL)-6-(1-METHYLETHYL)PIPERAZINE-2,5-DIONE
• CAS NO: 155322-96-6
• Molecular Formula: C8 H14 N2 O3
• Molecular Weight: 186.21
• Product Categories: PIPERIDINE
• Mol File: 155322-96-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 513.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.148±0.06 g/cm3(Predicted)
• PKA: 12.49±0.60(Predicted)
• CAS DataBase Reference: 2,5-Piperazinedione,3-(hydroxymethyl)-6-(1-methylethyl)-,(3R,6S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione,3-(hydroxymethyl)-6-(1-methylethyl)-,(3R,6S)-(9CI)(155322-96-6)
• EPA Substance Registry System: 2,5-Piperazinedione,3-(hydroxymethyl)-6-(1-methylethyl)-,(3R,6S)-(9CI)(155322-96-6)

Safety Data

• Hazardous Substances Data: 155322-96-6(Hazardous Substances Data)

Usage

Structure

2,5-Piperazinedione derivative with a hydroxymethyl group at position 3 and an isopropyl group at position 6

Stereochemistry

(3R,6S)-stereoisomer

Uses

Synthesis of pharmaceuticals and agrochemicals, intermediate in the synthesis of various organic compounds

Reactivity

High reactivity due to structural characteristics

Properties

Varies depending on the specific requirements of the end product.

Upstream product

• 119153-86-5 C₁₆H₂₁NO₆ 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 155225-25-5 N--(R)-serine methylester 
• 255869-54-6 (R)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-hydroxy-propionic acid methyl ester 

Downstream Products

• 155322-94-4 (2S,5S)-2-hydroxymethyl-5-iso-propylpiperazine 

Relevant articles and documents

The synthesis and conformational aspects of a novel dioxopiperazine - A possible β-turn constraint

The synthesis and conformational aspects of a dioxopiperazine was discussed. The cis configuration of the dioxopiperazine was rationalized using nuclear magnetic resonance (NMR) spectroscopy. Computational energy calculations were performed to explain the reluctance to cyclise of N-terminal partially protected dipeptides containing α, α-amino groups.

Chiral Ligands Containing Heteroatoms. 11. Optically Active 2-Hydroxymethyl Piperazines as Catalyst in the Enantioselective Addition of Diethylzinc to Benzaldehyde

Starting from enantiomerically pure serine, a series of (2R,5S) and (2S,5S)-2-hydroxymethyl-5-alkyl piperazines 1-5 were prepared in good yields without any racemization.The use of these compounds as chiral catalysts for the enantioselective addition of d