15533-09-2Relevant academic research and scientific papers
Syntheses and structural investigation of some alkali metal ion-mediated LVVO2- (L2- = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities
Dash, Subhashree P.,Panda, Alok K.,Pasayat, Sagarika,Dinda, Rupam,Biswas, Ashis,Tiekink, Edward R. T.,Patil, Yogesh P.,Nethaji,Kaminsky, Werner,Mukhopadhyay, Subhadip,Bhutia, Sujit K.
, p. 10139 - 10156 (2014)
Eight alkali metal ion-mediated dioxidovanadium(v), [{VVO 2L1-6}A(H2O)n]∝, complexes for A = Li+, Na+, K+ and Cs +, containing tridentate aroylhydrazonate ligands coordinating via ONO donor atoms, are described. All the synthesised ligands and the metal complexes were successfully characterised by elemental analysis, IR, UV-Vis and NMR spectroscopy. X-ray crystallographic investigation of 3, 5-7 shows the presence of distorted NO4 coordination geometries for LVO 2- in each case, and varying μ-oxido and/or μ-aqua bridging with interesting variations correlated with the size of the alkali metal ions: with small Li+, no bridging-O is found but four ion aggregates are found with Na+, chains for K+ and finally, layers for Cs+. Two (5) or three-dimensional (3, 6 and 7) architectures are consolidated by hydrogen bonding. The dioxidovanadium(v) complexes were found to exhibit DNA binding activity due to their interaction with CT-DNA by the groove binding mode, with binding constants ranging from 103 to 104 M-1. Complexes 1-8 were also tested for DNA nuclease activity against pUC19 plasmid DNA which showed that 6 and 7 had the best DNA binding and photonuclease activity; these results support their good protein binding and cleavage activity with binding constants ranging from 104 to 105 M-1. Finally, the in vitro antiproliferative activity of all complexes was assayed against the HeLa cell line. Some of the complexes (2, 5, 6 and 7) show considerable activity compared to commonly used chemotherapeutic drugs. The variation in cytotoxicity of the complexes is influenced by the various functional groups attached to the aroylhydrazone derivative.
A family of mixed-ligand oxidovanadium(v) complexes with aroylhydrazone ligands: A combined experimental and computational study on the electronic effects of para substituents of hydrazone ligands on the electronic properties, DNA binding and nuclease activities
Patra, Debashis,Biswas, Nirmalendu,Kumari, Bhavini,Das, Prolay,Sepay, Nayim,Chatterjee, Shamba,Drew, Michael G. B.,Ghosh, Tapas
, p. 92456 - 92472 (2015/11/18)
A new series of mixed-ligand oxidovanadium(v) complexes [VVO(HL1-4)(hq)] (1-4) have been synthesized using 2-hydroxybenzoylhydrazones of 2-hydroxyacetophenone and its 5-substituted derivatives (H3L1-4) along with 8-hydroxyquinoline (Hhq) as co-ligand. The complexes were characterized by elemental analyses, magnetic susceptibility measurements and various spectroscopic methods. Their electrochemical behaviour is also reported. X-ray crystallographic investigations of 1-4 show the presence of distorted octahedral geometries with O4N2 coordination environments for each of the four complexes. λmax values for the ligand-to-metal-charge-transfer (LMCT) transition, Ef values and the chemical shift parameters (δ) for the 51V NMR spectra of the complexes exhibit a linear relationship with the Hammett constant (σ) of the substituents. DFT methods were used to predict the bond lengths, bond angles, λmax values for electronic transitions and δ values of 51V NMR spectra, all of which are found to be in good agreement with experimental results. The stability of the complexes was also examined. All the complexes exhibit DNA binding activity with CT-DNA either by minor groove binding mode (for 1 and 4) or by partial intercalation mode (for 2 and 3). The complexes were also tested for DNA nuclease activity with pUC19 plasmid DNA and were found to produce both nicked coiled and linear forms. The DNA binding and nuclease activities of the complexes follow the order: 3 > 2 > 1 > 4, which is also the hydrazone ligands' basicity order, suggesting that the binding and cleavage efficiencies are proportional to the electron density on the vanadium centre. The results of DNA binding experiments are further supported by molecular docking studies.
SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
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Page/Page column 75, (2010/08/08)
The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.
