155335-21-0

Basic information

• Product Name: 2-(3-methylphenyl)ethynyltrifluoroacetanilide
• Synonyms: 2-(3-methylphenyl)ethynyltrifluoroacetanilide
• CAS NO: 155335-21-0
• Molecular Weight: 303.284
• Mol File: 155335-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-methylphenyl)ethynyltrifluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylphenyl)ethynyltrifluoroacetanilide(155335-21-0)
• EPA Substance Registry System: 2-(3-methylphenyl)ethynyltrifluoroacetanilide(155335-21-0)

Safety Data

• Hazardous Substances Data: 155335-21-0(Hazardous Substances Data)

Upstream product

• 32578-31-7 3-tolyl triflate 
• 143360-93-4 N-(2-ethynylphenyl)-2,2,2-trifluoroacetamide 

Relevant articles and documents

2-Substituted-3-acylindoles through the palladium-catalysed carbonylative cyclization of 2-alkynyltrifluoroacetanilides with aryl halides and vinyl triflates

The palladium-catalysed reaction of readily accessible 2- alkynyltrifluoroacetanilides with aryl halides and vinyl triflates under a carbon monoxide atmosphere (1 or 7 atm) and in the presence of potassium carbonate produces 2-substituted-3-acyl indoles in fair to good yield. The acidity of the nitrogen-hydrogen bond proved to be of primary importance for the success of the reaction. The methodology has been applied to the synthesis of pravadoline, a drug that shows analgesic activity against postoperative pain in man.