155342-87-3Relevant academic research and scientific papers
Nicorandil analogues containing NO-donor furoxans and related furazans
Boschi, Donatella,Cena, Clara,Di Stilo, Antonella,Fruttero, Roberta,Gasco, Alberto
, p. 1727 - 1732 (2000)
The synthesis and in vitro vasodilating properties of hybrid compounds in which furoxan (1,2,5-oxadiazole 2-oxide) moieties, endowed with different NO-donor properties, were substituted for the nitroxy function of Nicorandil are reported. The corresponding cyanoguanidine analogues are also considered. This approach has led to a series of vasorelaxing compounds devoid of affinity for K(ATP) channels, whose activity is prevalently due to their ability to activate sGC, at the concentrations of the experiments. Related furazan (1,2,5-oxadiazole) derivatives, unable to release nitric oxide were also prepared and studied for control. The amide analogues of Nicorandil display feeble vasorelaxing action not involving the activation of K+ channels, while in the guanidine analogues, this mechanism seems to underlie this action. Copyright (C) 2000 Elsevier Science Ltd.
PYRIDYL CYANOGUANIDINE DERIVATIVES
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Paragraph 0143, (2013/03/26)
Compounds of formula (I) or pharmaceutically acceptable salts thereof, and use for treating cancer thereof are disclosed, wherein, the definitions of X, Y, R1, R2 and n are described in description.
Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3
Malerich, Jeremiah P.,Lam, Jennifer S.,Hart, Barry,Fine, Richard M.,Klebansky, Boris,Tanga, Mary J.,D'Andrea, Annalisa
scheme or table, p. 7454 - 7457 (2011/01/12)
Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.
Arylcyanoguanidines as activators of Kir6.2/SUR1KATP channels and inhibitors of insulin release
Tagmose, Tina M.,Schou, S?ren C.,Mogensen, John P.,Nielsen, Flemming E.,Arkhammar, Per O. G.,Wahl, Philip,Hansen, Birgit S.,Worsaae, Anne,Boonen, Harrie C. M.,Antoine, Marie-Hélène,Lebrun, Philippe,Hansen, John Bondo
, p. 3202 - 3211 (2007/10/03)
Phenylcyanoguanidines substituted with lipophilic electron-withdrawing functional groups, e.g. N-cyano-N′ -[3,5-bis-(trifluoromethyl)phenyl]-N″-(cyclopentyl)guanidine (10) and N-cyano-N′-(3,5-dichlorophenyl)-N′-(3-methylbutyl)guanidine (12) were synthesiz
