155346-24-0Relevant academic research and scientific papers
Synthesis of imidazo[1′,5′:1,2]pyrido [3,4-b]indole derivatives
Solymar, Magdolna,Palko, Marta,Martinek, Tamas,Fueloep, Ferenc
, p. 1423 - 1430 (2002)
The reactions of 1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid and its ethyl ester with alkyl and aryl isothiocyanates under mild conditions resulted in the corresponding thiohydantoin-fused tetrahydro-β-carbolines. Treatment of the ethyl ester with isocyanates furnished ethyl 2-alkyl- or arylcarbamoyl-1,2,3,4-tetrahydro-β-carboline-1-carboxylates which were transformed to hydantoinfused tetrahydro-β-carbolines. The structures of the thiohydantoin compounds, involving two conformers and the presence of keto-enol tautomerism, were determined by NMR spectroscopy.
Reaction Of Tetrahydro-β-Carboline-1-Carboxylic Acid With Isocyanates And Isothiocyanates. Synthesis Of 1-Alkyl- Or Arylcarbamoyl-β-Carbolines
Lopez-Rodriguez. Maria L.,Morcillo, M. Jose,Gil, Pedro J.,Rosado, M. Luisa,Ventura, M. Paz
, p. 1053 - 1068 (2007/10/02)
The reaction of (+/-)-1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid (8) with alkyl and aryl isocyanates formed the corresponding tetrahydro-β-carboline-hydantoin ring systems (7).However the reaction of 8 with isothiocyanates provided 2-alkyl- or arylthiocarbamoyl-1,2,3,4-tetrahydro-β-carbolines (9).The oxidation of 7 with selenium dioxide or dichlorodicyano-p-benzoquinone gave 1-substituted β-carbolines (10) related to β-carboline alkaloids.
