155346-54-6 Usage
Uses
Used in Pharmaceutical Industry:
[(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid is used as an intermediate compound for the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. Its nitrogen-containing nature and the presence of a piperidine ring make it a versatile building block for the development of new drugs with potential applications in treating various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, [(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid may be used as a starting material or intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties and reactivity can be exploited to create novel compounds with improved efficacy and selectivity, contributing to more effective and environmentally friendly agricultural practices.
Used in Organic Synthesis:
As a reagent in organic synthesis, [(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid can be employed in the preparation of a wide range of organic compounds. Its unique structure and functional groups allow for various chemical reactions, enabling the synthesis of complex molecules with potential applications in different fields, such as materials science, pharmaceuticals, and agrochemicals.
Used in Liquid Chromatography:
In the field of analytical chemistry, [(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid serves as a mobile phase modifier in liquid chromatography. Its addition to the mobile phase can improve the separation and resolution of complex mixtures, leading to more accurate and reliable analytical results. This application is particularly relevant in the quality control and analysis of pharmaceuticals, agrochemicals, and other chemical products.
Further research and assessment are necessary to fully understand the characteristics and potential uses of [(Piperidine-2-carbonyl)-amino]-acetic acid methyl ester; compound with trifluoro-acetic acid, as its unique chemical properties and reactivity may open up new avenues in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 155346-54-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,3,4 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 155346-54:
(8*1)+(7*5)+(6*5)+(5*3)+(4*4)+(3*6)+(2*5)+(1*4)=136
136 % 10 = 6
So 155346-54-6 is a valid CAS Registry Number.
155346-54-6Relevant academic research and scientific papers
Synthesis and Evaluation of Conformationally Restricted N--N-methyl-2-(1-pyrrolidinyl)ethylamines at ? Receptors. 2. Piperazines, Bicyclic Amines, Bridged Bicyclic Amines, and Miscellaneous Compounds
Costa, Brian R. de,He, Xiao-shu,Linders, Joannes T.M.,Dominguez, Celia,Gu, Zi Qiang,et al.
, p. 2311 - 2320 (2007/10/02)
As a continuation of our earlier study (J.Med.Chem. 1992, 35, 4334-4343) we conformationally restricted the ?-receptor ligand 2-(1-pyrrolidinyl)-N--N-methylethylamine (1) by incorporating it into a series of homologous piperazines 3-9 and homopiperazines 10 and 11, diazabicyclononanes and decanes, bridgehead bicyclooctanes and nonanes as well as other miscellaneous compounds. ?-Receptor binding affinites were obtained using (+)-pentazocine in guinea pig brain membrane ?1 sites.The studies suggest that the nitrogen lone pair orient ation found in the piperazines affords the strongest binding interaction.Other nitrogen lone pair orientations or compounds representing unlikely staggered conformations of 1 -1,4-diazabicyclononane (16)> show very weak ? interaction.Comperison of the binding data of different N-substituted homologues of 1 with those of the 1--4-alkylpiperazines suggests that the two nitrogen atoms of 1 are working in opposition to one another in terms of their sensitivity to steric bulk.The high binding affinity of the 1,4-diazabicyclononanes 12 suggests that these may approximate the methyl and pyrrolidine ring conformations found in 1 when it is bound to the ? receptor.Compound 12 exhibited a 4-fold enantioselectivity favoring (+)-12.The synthesis of 6,7-dichloro-2-amino>tetralin (19) and its desmethyl derivative 20 permitted constraint of the 3,4-dichlorophenyl and N-methyl moieties of 1 into a gauche orientation.The binding data suggests that this conformation in 1 favors strong binding interaction at ?-receptors. ?-Receptor K1's ra nged from 0.55 nM for 1--4-n-butylpiperazine (7) to 654 nM for 16.Overall comparison of the results indicate that 1 is subject to considerable conformational freedom and suggests that the ?-receptor is not subject to rigid stereochemical restraints with 1.These results add to our earlier study where we restrained 1 using simple monocyclic heterocycles.
