155374-25-7Relevant articles and documents
Reaction of 5-aminopyrazole derivatives with ethoxymethylene- malononitrile and its analogues
Nagahara,Kawano,Sasaoka,Ukawa,Hirama,Takada,Cottam,Robins
, p. 239 - 243 (2007/10/02)
A one-pot synthesis using 5-aminopyrazole derivatives 1 with ethoxymethylenemalononitrile (EMMN), ethyl ethoxymethylenecyanoacetate (EMCA) or diethyl ethoxymethylenemalonate (DEMM) gave pyrazolo-[1,5-a]pyrimidine compounds 2,4,8. Also, the one step reaction of EMCA with hydrazine hydrate afforded ethyl(4-ethoxycarbonyl-5-pyrazolyl)aminomethylenecyanoacetate 3c. On the other hand, the reaction of 1-substituted 5-aminopyrazole-4-carboxamide 9 with EMMN afforded pyrazolo[3,4-d]pyrimidine compounds 10.