155375-23-8

Basic information

• Product Name: 2-Propenamide,3-(2-pyridinyl)-,(Z)-(9CI)
• Synonyms: 2-Propenamide,3-(2-pyridinyl)-,(Z)-(9CI)
• CAS NO: 155375-23-8
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16
• Product Categories: PYRIDINE
• Mol File: 155375-23-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 376.6±34.0 °C(Predicted)
• Appearance: /
• Density: 1.190±0.06 g/cm3(Predicted)
• PKA: 14.49±0.50(Predicted)
• CAS DataBase Reference: 2-Propenamide,3-(2-pyridinyl)-,(Z)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide,3-(2-pyridinyl)-,(Z)-(9CI)(155375-23-8)
• EPA Substance Registry System: 2-Propenamide,3-(2-pyridinyl)-,(Z)-(9CI)(155375-23-8)

Safety Data

• Hazardous Substances Data: 155375-23-8(Hazardous Substances Data)

Usage

Derivative of

Acrylamide

Industrial Use

Used in the production of various polymers and industrial chemicals.

Potential Applications

Medicinal Chemistry: Used as a building block in the synthesis of pharmaceutical compounds.
Biochemical Research: Employed in the synthesis of biologically active molecules.

Safety Concerns

Handle with care due to the potential toxicity and carcinogenicity associated with acrylamide derivatives.

Upstream product

• 99584-02-8 (E)-3-(pyridin-2-yl)acrylamide 
• 1945-84-2 2-ethynylpyridine 
• 72764-93-3 methyl 3-(pyridin-2-yl)propiolate 
• 109-04-6 2-bromo-pyridine 
• 79-06-1 2-propenamide 
• 110-86-1 pyridine 
• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 
• 7340-23-0 (E)-ethyl 3-(2-pyridyl)-propenoate 

Downstream Products

• 155375-22-7 (Z)-3-(2-Pyridyl)propenamide 
• 39077-58-2 3-(2-pyridyl)-prop-2-enyl nitrile 

Relevant articles and documents

Catalytic, transition-metal-free semireduction of propiolamide derivatives: Scope and mechanistic investigation

We report a transition-metal-free trans-selective semireduction of alkynes with pinacolborane and catalytic potassium tert-butoxide. A variety of 3-substituted primary and secondary propiolamides, including an analog of FK866, a potent nicotinamide mononucleotide adenyltransferase (NMNAT) inhibitor, are reduced to the corresponding (E)-3-substituted acrylamide derivatives in up to 99% yield with >99:1 E/Z selectivity. Mechanistic studies suggest that an activated Lewis acid-base complex transfers a hydride to the α-carbon followed by rapid protonation in a trans fashion.

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

This is the first report of 5-styryl-oxathiazol-2-ones as inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome. As part of the study, the structure-activity relationship of oxathiazolones as Mtb proteasome inhibitors has been investigated. Furthermore, the prepared compounds displayed a good selectivity profile for Mtb compared to the human proteasome. The 5-styryl-oxathiazol-2-one inhibitors identified showed little activity against replicating Mtb, but were rapidly bactericidal against nonreplicating bacteria. (E)-5-(4-Chlorostyryl)-1,3,4-oxathiazol-2-one) was most effective, reducing the colony-forming units (CFU)/mL below the detection limit in only seven days at all concentrations tested. The results suggest that this new class of Mtb proteasome inhibitors has the potential to be further developed into novel antitubercular agents for synergistic combination therapies with existing drugs.

Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof

The present invention is directed to compounds effective for increasing the water solubility of poorly soluble drugs. Hydrotropic agents are identified, such as for increasing the solubility of paclitaxel. Polymerizable monomers of the hydrotropic agents