155395-70-3

Basic information

• Product Name: (2S,3S,8aR)-3-Methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• Synonyms: (2S,3S,8aR)-3-Methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• CAS NO: 155395-70-3
• Molecular Weight: 275.348
• Mol File: 155395-70-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,3S,8aR)-3-Methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S,8aR)-3-Methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(155395-70-3)
• EPA Substance Registry System: (2S,3S,8aR)-3-Methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(155395-70-3)

Safety Data

• Hazardous Substances Data: 155395-70-3(Hazardous Substances Data)

Upstream product

• 116950-01-7 (2S,3S,8aR)-Hexahydro-3-(hydroxymethyl)-8a-methyl-2-phenyl-5-oxo-5H-oxazolo<3,2-a>pyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 155395-75-8 (2S,3S,8aR)-3-Methoxymethyl-6,8a-dimethyl-2-phenyl-5-((E)-3-phenyl-allylsulfanyl)-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine 
• 155395-80-5 (2S,3S,6S,8aR)-6-(1,1-Dimethyl-allyl)-3-methoxymethyl-6,8a-dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione 
• 155395-73-6 (2S,3S,8aR)-3-Methoxymethyl-6,8a-dimethyl-5-(2-methyl-allylsulfanyl)-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine 
• 155395-76-9 (2S,3S,8aR)-3-Methoxymethyl-6,8a-dimethyl-5-(3-methyl-but-2-enylsulfanyl)-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine 
• 155395-74-7 (2S,3S,8aR)-5-[((E)-But-2-enyl)sulfanyl]-3-methoxymethyl-6,8a-dimethyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine 
• 155395-84-9 (S)-2-(1,1-Dimethyl-allyl)-2-methyl-5-oxo-hexanal 
• 155395-83-8 (S)-2-Methyl-2-((R)-1-methyl-allyl)-5-oxo-hexanal 
• 191805-32-0 (2S,3S,8aR)-3-Methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione 
• 207977-94-4 (2S,3S,8aR)-3-Methoxymethyl-6,8a-dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one 
• 169331-39-9 (S)-3-benzylcyclohexanone 
• 1026043-64-0 (2S,3S,7S,8aR)-7-Benzyl-3-methoxymethyl-8a-methyl-2-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 191805-58-0 (2S,3S,7S,8aR)-7-Benzyl-3-methoxymethyl-8a-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one 

Relevant articles and documents

Chiral bicyclic lactams as homoenolate equivalents: An asymmetric route to 5-substituted cyclohexenones

Bicyclic Lactam 2 was transformed info α-cyanoenamine 8 in a four- step, high-yielding process. γ-Metalation of 8 was achieved using LiTMP in THF/HMPA, and the resultant homoenolate equivalent underwent stereoselective alkylation and subsequent hydrolysis to provide lactams of type 10 as a single diasteraomer. Partial reduction and hydrolysis of lactams 10 furnished enantiopure 5-substituted cyclohexenones 13 in good overall yield.