155405-81-5

Basic information

• Product Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester
• Synonyms: 4-[2-(2-AMino-4-oxo-4,7-Dihydro-3H-pyrrolo[2,3-d]pyriMidine-5-yl)ethyl]-L-GlutaMicAcidDiethylEsterP-TluensulfonicAcidsalt;N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester;Pemetrexed methyl ester;PeMetrexed DiMethyl Ester;N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid dimethyl ester
• CAS NO: 155405-81-5
• Molecular Formula: C₂₂H₂₅N₅O₆
• Molecular Weight: 455.4638
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 155405-81-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Dimethylformamide, DMSO, Methanol
• PKA: 13.01±0.46(Predicted)
• CAS DataBase Reference: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester(155405-81-5)
• EPA Substance Registry System: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester(155405-81-5)

Safety Data

• Hazardous Substances Data: 155405-81-5(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Protected Pemetrexed.

Upstream product

• 157848-17-4 4-(3-hydroxy-4,4-dimethoxybutyl)benzoic acid methyl ester 
• 1007376-45-5 C₁₅H₁₃N₄O₃^(1-)*Na⁽¹⁺⁾ 
• 155405-80-4 C₁₆H₁₆N₄O₃ 
• 157848-19-6 4-{3-[(methylsulfonyl)oxy]-4-oxobutyl}benzoic acid methyl ester 
• 157848-18-5 4-{3-[(methylsulfonyl)oxy]-4,4-dimethoxybutyl}benzoic acid methyl ester 
• 137281-39-1 C₁₅H₁₄N₄O₃ 
• 23150-65-4 L-glutamic dimethyl ester hydrochloride 
• 1571-08-0 methyl 4-formylbenzoate 
• 137281-39-1 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid 

Downstream Products

• 1006872-74-7 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid monosodium salt 

Relevant articles and documents

PROCESS FOR PREPARING PEMETREXED DI POTASSIUM AND ITS HYDRATES

The present invention relates to Di potassium (S)-2-(4-(2-(2-amino-4-oxo4,7,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido) pentanedioate (I) and its hydrates useful as active pharmaceutical ingredient in pharmaceutical compositions for the tre

A NEW CRYSTALLINE FORM OF PEMETREXED DISODIUM

The present invention relates to a new polymorphic or crystalline form of Pemetrexed Disodium, processes for its preparation and its use, in particular for the preparation of medicaments.