155427-30-8

Basic information

• Product Name: 2H-1-Benzopyran-2-carbonyl chloride, 6-fluoro-3,4-dihydro-, (S)- (9CI)
• Synonyms: 2H-1-Benzopyran-2-carbonyl chloride, 6-fluoro-3,4-dihydro-, (S)- (9CI)
• CAS NO: 155427-30-8
• Molecular Formula: C10H8ClFO2
• Molecular Weight: 214.6207232
• Product Categories: ACIDHALIDE
• Mol File: 155427-30-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 295.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2H-1-Benzopyran-2-carbonyl chloride, 6-fluoro-3,4-dihydro-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-carbonyl chloride, 6-fluoro-3,4-dihydro-, (S)- (9CI)(155427-30-8)
• EPA Substance Registry System: 2H-1-Benzopyran-2-carbonyl chloride, 6-fluoro-3,4-dihydro-, (S)- (9CI)(155427-30-8)

Safety Data

• Hazardous Substances Data: 155427-30-8(Hazardous Substances Data)

Upstream product

• 99199-60-7 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 129101-36-6 (S)-6-fluorochroman-2-carboxylic acid 

Downstream Products

• 793669-26-8 [1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 793669-26-8 [1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 943126-72-5 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one 
• 878208-57-2 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid piperidine amide 

Relevant articles and documents

MOST EFFECTIVE PROCESS FOR BASE-FREE PREPARATION OF KETONE INTERMEDIATES USABLE FOR MANUFACTURE OF NEBIVOLOL

The invention relates to a process for the preparation of a ketone of a general formula 1 with X being Cl or Br, in particular with X being Cl, with Y being F, Cl, Br, I or H, in particular with Y being F, comprising the steps of: activation of a carboxylic acid by using a peptide coupling agent, coupling of the activated carboxylic acid with a malonic acid derivative providing a β-ketoester precursor and converting the β-ketoester precursor to the ketone of the general formula 1.

PROCESS FOR PREPARING NEBIVOLOL

The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.

Process for preparation of racemic Nebivolol

A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compo