15548-52-4 Usage
Uses
Used in Pharmaceutical Industry:
Uridine, 5'-(dihydrogen phosphorothioate) is used as a component in the development of nucleic acid-based therapeutics for its ability to enhance the stability and binding affinity of antisense oligonucleotides to their target RNA molecules. This modification contributes to the improvement of pharmacokinetic properties and therapeutic outcomes.
Used in Research Applications:
In the field of molecular biology and genetics, Uridine, 5'-(dihydrogen phosphorothioate) serves as a research tool for studying gene expression and regulation. Its enhanced cellular uptake and nuclease resistance make it a valuable asset in experimental designs requiring the manipulation of RNA targets.
Used in Drug Delivery Systems:
Uridine, 5'-(dihydrogen phosphorothioate) is utilized in the design of drug delivery systems to improve the bioavailability and therapeutic efficacy of antisense oligonucleotides. Its incorporation into these systems aids in overcoming limitations associated with the delivery of nucleic acid-based therapeutics, thus enhancing their clinical potential.
Check Digit Verification of cas no
The CAS Registry Mumber 15548-52-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,4 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15548-52:
(7*1)+(6*5)+(5*5)+(4*4)+(3*8)+(2*5)+(1*2)=114
114 % 10 = 4
So 15548-52-4 is a valid CAS Registry Number.
15548-52-4Relevant academic research and scientific papers
PREPARATION OF DERIVATIVES OF INOSINE 5'-PHOSPHOROTHIOATE FOR USE IN AFFINITY CHROMATOGRAPHY
Kois, Pavol,Holy, Antonin
, p. 2830 - 2838 (2007/10/02)
In the paper the known methods of preparation of ribonucleoside 5'-phosphorothioates II are evaluated and an improved method of their synthesis is described, based on the reaction of 2',3'-O-ethoxymethyleneribonucleosides III with thiophosphoryl chloride in the presence of one equivalent of pyridine, and subsequent hydrolysis.Inosine 5'-phosphate and inosine 5'-phosphorothioate (IIc) were converted to 2',3'-O-cyclic ketals of levulinic acid Vb, VIb on reaction with ethyl levulinate and ethyl orthoformate and subsequent alkaline hydrolysis.O-(4-Aminophenyl)inosine 5'-phosphorothioate (IX) was prepared from 2',3'-O-isopropylideneinosine (VII) with O-(4-nitrophenyl)thiophosphoryldiimidazolide and subsequent catalytic hydrogenation of the O-(4-nitrophenyl) ester VIII formed.
