155488-25-8

Basic information

• Product Name: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea
• Synonyms: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea;Sograzepide;Estradiol-3-O-sulfamate;1-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea
• CAS NO: 155488-25-8
• Molecular Formula: C₂₈H₃₀N₆O₃
• Molecular Weight: 498.58
• EINECS: 604-604-1
• Mol File: 155488-25-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 723.049 °C at 760 mmHg
• Flash Point: 391.086 °C
• Appearance: /
• Density: 1.25
• PKA: 11.38±0.40(Predicted)
• CAS DataBase Reference: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea(155488-25-8)
• EPA Substance Registry System: N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea(155488-25-8)

Safety Data

• Hazardous Substances Data: 155488-25-8(Hazardous Substances Data)

Usage

Uses

Sograzepide is used in the treatment of gastric carcinoids or patients with chronic atrophic gastritis. Gastric receptor antagonist.

Upstream product

• 186086-59-9 [1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 164343-31-1 (R)-3-Amino-1-(3,3-dimethyl-2-oxo-butyl)-5-pyridin-2-yl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 168162-32-1 3-[N-(tert-butoxycarbonyl)-N-methyl-amino]phenyl isocyanate 
• 168162-30-9 3-(N-tert-butoxycarbonyl-N-methyl-amino)-benzoic acid 
• 168162-22-9 (3RS)-Amino-1-(tert-butylcarbonylmethyl)-2,3-dihydro-5-(pyridin-2-yl)-1H-1,4-benzodiazepin-2-one 
• 152665-84-4 1,3-dihydro-5-(pyridin-2-yl)-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one 
• 111331-82-9 3-[(tert-butoxycarbonyl)amino]benzoic acid 
• 99-05-8 meta-aminobenzoic acid 
• 42471-56-7 2-(2-aminobenzoyl)pyridine 

Relevant articles and documents

Benzodiazepine derivatives useful as CCK-receptor antagonists

This invention relates to benzodiazepine derivatives which are useful as drugs exhibiting antagonism at the gastrin and/or CCK-B receptor, and to their production.