1555880-99-3Relevant academic research and scientific papers
Beyond the roche ester: A new approach to polypropionate stereotriad synthesis
Foley, Corinne N.,Leighton, James L.
, p. 1180 - 1183 (2014/03/21)
An efficient, step-economical, and scalable approach to the synthesis of polypropionate stereotriads has been developed. Either 2-butyne or propyne is subjected to rhodium-catalyzed silylformylation and in situ crotylation of the resulting aldehydes. Tamao oxidation under either standard conditions or aprotic conditions then delivers the completed stereotriads in a three-step, two-pot sequence. In contrast to the classical Roche ester approach, the α-stereocenter is obtained for free.
