155593-75-2Relevant articles and documents
Acid-catalysed deuterium exchange of aromatic protons. Part III: Accelerated exchange by microwave irradiation
Koves
, p. 255 - 262 (2007/10/02)
Conventional acid-catalysed 2H/1H exchange in aromatic rings requires long reaction times, high temperatures and pressure. This paper reports that accelerated deuterium exchange can be achieved in a microwave oven. Experiments were carried out on benzodiazepines, tricyclic antidepressants and phenothiazines. The reaction time was decreased from days to minutes, the preparatory work was simpler than with conventional heating and the labelled products were cleaner