155601-30-2

Basic information

• Product Name: 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate
• Synonyms: 4,5-DIAMINO-(2-HYDROXYETHYL)PYRAZOLE SULFATE;4,5-DIAMINO-1-(2-HYDROXYETHYL)-1H-PYRAZOLE SULFATE;4,5-DIAMINO-1-(2-HYDROXY)ETHYL PYRAZOLE SULFATE;4,5-DIAMINO-1-(2-HYDROXYETHYL)PYRAZOLE SULPHATE;P5 SULFATE;4,5-Diamino-1-(2-Hydroxyethyl)-1h-Pyazolsulfate;1-HYDROXYETHYL 4,5-DIAMINO PYRAZOLE SULFATE;4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate (P5)
• CAS NO: 155601-30-2
• Molecular Formula: C₅H₁₀N₄O*H₂O₄S
• Molecular Weight: 240.24
• EINECS: 429-300-3
• Product Categories: Pyrazole
• Mol File: 155601-30-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: >183℃
• Boiling Point: 407.4 °C at 760 mmHg
• Flash Point: 200.2 °C
• Appearance: Off-white to pink powder
• Density: 1.69-1.87 at 20℃
• Vapor Pressure: 2.29E-07mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate(155601-30-2)
• EPA Substance Registry System: 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate(155601-30-2)

Safety Data

• Hazard Codes: Xi,N
• Statements: 41-43-51/53
• Safety Statements: 24-26-37/39-61
• Hazardous Substances Data: 155601-30-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to pink powder

Uses

4,5-Diamino-1-(2-hydroxyethyl)pyrazole Sulfate is useful as an oxidative hair dye.

InChI:InChI=1/C5H10N4O.H2O4S/c6-4-3-8-9(1-2-10)5(4)7;1-5(2,3)4/h3,10H,1-2,6-7H2;(H2,1,2,3,4)

Upstream product

• 128564-63-6 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole 
• 109-84-2 2-hydroxyethylhydrazine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 924897-89-2 5-amino-1-(2'-hydroxyethyl)-4-phenylazopyrazole hydrochloride 

Downstream Products

• 1161138-71-1 4-[5-amino-1-(2-hydroxyethyl)-1H-pyrazol-4-ylimino]-3-hydroxy-2-methyl-cyclohexa-2,5-dienone 
• 1161138-59-5 2-[5-amino-1-(2-hydroxyethyl)-1H-pyrazol-4-ylamino]-5-(2-hydroxyethyl-amino)[1,4]benzoquinone 
• 1161138-87-9 2-[5-amino-1-(2-hydroxyethyl)-1H-pyrazol-4-ylamino]-4-[5-amino-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylimino]-5-hydroxycyclo-hexa-2,5-dienone 
• 1161138-64-2 3-amino-4-[5-amino-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylimino]-2-chloro-6-methylcyclohexa-2,5-dienone 
• 1020848-89-8 2-{5-amino-4-[(4-{[5-amino-1-(2-hydroxyethyl)-1H-pyrazol-4-ylimino]-methyl}-benzylidene)-amino]-pyrazol-1-yl}-ethanol 
• 1020848-83-2 2-hydroxyethyl-4,5-bis-(benzylidene-amino)-pyrazole 
• 1020848-81-0 2-hydroxyethyl-4-(4-nitrobenzylidene)-amino-5-amino-pyrazole 

Relevant articles and documents

Preparation method of 4,5-diamino-1-(2-hydroxyethyl)pyrazole sulfate

The invention relates to a preparation method of 4,5-diamino-1-(2-hydroxyethyl)pyrazole sulfate. Diethyl ethoxymethylenemalonate is taken as an initial raw material and cyclized with 2-hydroxyethyl inethyl alcohol, and then the 4,5-diamino-1-(2-hydroxyethyl)pyrazole sulfate is prepared through hydrolysis, acidization, decarboxylation, nitrosation, reduction and sulfuric acid salifying. Accordingto the preparation method of the 4,5-diamino-1-(2-hydroxyethyl)pyrazole sulfate, by-products are few, a prepared product is high in purity, meanwhile a process is simplified, the synthesis period is shortened, and meanwhile expansion and popularization are also facilitated.

CEPHEM COMPOUNDS

The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is ; R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Preparation of 4,5-diamino-1-(2′-hydroxyethyl)-pyrazole and acid addition salts thereof

Disclosed is an improved process for the preparation of 4,5-diamino-1-(2′-hydroxyethyl)pyrazole and acid addition salts thereof such as the addition salt from sulfuric acid. The process comprises a novel combination of steps beginning with an alkyl(alkoxymethylene)cyanoacetate and 2-hydroxyethylhydrazine and the formation of intermediate compounds 5-amino-4-alkoxycarbonyl-1-(2′-hydroxyethyl)pyrazole (I), 5-amino-4-carboxyl-1-(2′-hydroxyethyl)pyrazole (II), 5-amino-1-(2′-hydroxyethyl)pyrazole (III), 5-amino-1-(2′-hydroxyethyl)4-nitrosopyrazole (IV).