155652-05-4Relevant academic research and scientific papers
Cyclisation of (E)- and (Z)-3-ethoxycarbonyl-4-methyl-4-(3'-chloro-6'-methylphenyl)but-3-enoic acids and synthesis of polysubstituted naphthoic acids
Mahmoud, M. R.
, p. 1028 - 1032 (2007/10/02)
Condensation of 5-chloro-2-methylacetophenone with diethyl succinate in the presence of potassium t-butoxide gives a mixture of (Z)- and (E)-3-ethoxycarbonyl-4-methyl(3'-chloro-6'-methylphenyl)but-3-enoic acids.Cyclisation of (Z)- and (E)-half-esters affords naphthalene derivative (2a) and oxo-indenyl acid (11) respectively via anhydride formation.The reaction of (E)-anhydride (4) with aromatic hydrocarbons, amines and anhyd. aluminium chloride in acetylene tetrachloride has also been investigated.The IR, H1NMR and mass spectra of the products have been discussed.
