155653-55-7Relevant academic research and scientific papers
Catalytic arylation of a C-H bond in pyridine and related six-membered N-heteroarenes using organozinc reagents
Hyodo, Isao,Tobisu, Mamoru,Chatani, Naoto
supporting information; experimental part, p. 1357 - 1365 (2012/08/08)
Despite significant advances in the catalytic direct arylation of heteroarenes, the application of this reaction to pyridines has been met with limited success. An oxidative nucleophilic arylation strategy has been developed to overcome this problem. Pyridine, pyrazine, quinolone, and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using the developed nickel-catalyzed reaction. This protocol serves as a complementary method to catalytic direct arylation reactions. Less is more: Pyridine, pyrazine, quinoline and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using organozinc reagents through nickel catalysis. This protocol serves as a complementary method to catalytic direct arylation reactions. Copyright
REACTIVITY OF PHENYLLITHIUM TOWARD BRIDGEHEAD NITROGEN HETEROCYCLES
Gueiffier, Alain,Viols, Henri,Blache, Ives,Chavignon, Olivier,Teulade, Jean Claude,et al.
, p. 551 - 558 (2007/10/02)
The reactivity of phenyllithium toward some bridgehead nitrogen heterocycles was investigated.Imidazopyridine gave the substitution, while other series gave addition reactions.In addition, the ring opening derivative was obtained in imidazoquinazoline series.
