15566-80-0Relevant articles and documents
Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines
Zorko, Mateja,Majerle, Andreja,Sarlah, David,Keber, Mateja Mancek,Mohar, Barbara,Jerala, Roman
, p. 2307 - 2313 (2005)
A combination of antimicrobial and endotoxin-neutralizing activities is desired in order to prevent progression from infection to sepsis due to the release of lipopolysaccharide from dying gram-negative bacteria. Lipopolyamines have emerged as a new type of endotoxin-neutralizing compound, but their antimicrobial activity has not been investigated. We synthesized a series of 10 oleoylamines differing in the polyamino head group, particularly in the number and separation between nitrogen atoms and the position of the oleoyl moiety. Compounds showed activity against both gram-negative and gram-positive bacteria in the micromolar range. Compounds were able to provide penetration of ethidium bromide into bacteria, indicating effects on the bacterial membrane. Oleoylamines neutralized endotoxin in Limulus amoebocyte lysate assays and by neutralization of tumor necrosis factor alpha release in human blood. Comparison of biological activities of compounds identified structural properties responsible for antimicrobial activity, and quantitative structure-property relationship analysis provided a quantitative model for prediction of activity of oleoylamines. Copyright
Imidazoline Mannich base corrosion inhibitor and preparation method thereof
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Paragraph 0033; 0045; 0054; 0063; 0072, (2019/10/01)
The invention relates to the technical field of corrosion inhibitors, and in particular relates to an imidazoline mannich base corrosion inhibitor and a preparation method thereof. The imidazoline mannich base corrosion inhibitor is of the structure shown in the formula I. The imidazoline mannich base corrosion inhibitor is prepared from, by mass, 10-20% of benzaldehyde, 5-15% of butanone, 40-60%of oleic acid imidazoline, 10-30% of ethanol, 1-5% of concentrated hydrochloric acid and 0.1-0.5% of a catalyst. According to the imidazoline mannich base corrosion inhibitor, a benzene ring, an imidazole ring and an ultra-long hydrophobic alkyl chain on imidazoline are introduced, the benzene ring in benzaldehyde and N atoms in the imidazoline ring have relatively high electron cloud density andcan form a firm coordination bond with an empty d track of metal, and the super-long hydrophobic alkyl chain forms a hydrophobic membrane layer away from the surface of the metal and has a peripheralshielding effect on the surface of the metal, so that the corrosion inhibitor has excellent corrosion inhibition performance in a high-temperature acidification environment.
