155672-61-0Relevant articles and documents
SYNTHESIS AND ANTIVIRAL ACTIVITY OF ACYCLIC NUCLEOSIDE ANALOGUES OF 6-METHYLURACIL AND 4-ALKYLAMINO-6-METHYL-2(1H)-PYRIMIDINONES
Bhat, Sunita
, p. 683 - 690 (2007/10/02)
Reaction of 2,4-dimethoxy-6-methylpyrimidine (I) with allyl bromide or benzyl bromide afforded 1-substituted 4-methoxy-6-methyl-2(1H)-pyrimidinone intermediates III, X.Oxidation of the compound III afforded racemic cis diol VI.O-Demethylation and nucleophilic displacement of the intermediates III, VI, and X gave 1-substituted 6-methyluracils IV, VII, IX and 1-substituted 4-alkylamino-6-methyl-2(1H)-pyrimidinones V, VIII, XII in good yields.The compounds II - XII were evaluated against Ranikhet desease virus (RDV); compounds Vb, Vii, X, XIIb - XIId showed 100, 43, 44, 75, 72 and 100percent inhibition, respectively.