155681-21-3

Basic information

• Product Name: (2-HydroxyMethyl-pyrrolidin-1-yl)-acetic acid
• Synonyms: (2-HydroxyMethyl-pyrrolidin-1-yl)-acetic acid
• CAS NO: 155681-21-3
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.18302
• Mol File: 155681-21-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-HydroxyMethyl-pyrrolidin-1-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HydroxyMethyl-pyrrolidin-1-yl)-acetic acid(155681-21-3)
• EPA Substance Registry System: (2-HydroxyMethyl-pyrrolidin-1-yl)-acetic acid(155681-21-3)

Safety Data

• Hazardous Substances Data: 155681-21-3(Hazardous Substances Data)

Usage

General Description

(2-HydroxyMethyl-pyrrolidin-1-yl)-acetic acid, also known as hydramethylnon, is a chemical compound commonly used as an insecticide and pesticide. It works by interfering with the insect's nervous system, leading to paralysis and eventually death. Hydramethylnon is particularly effective against ants, cockroaches, and other crawling insects, making it a popular choice for pest control in residential and commercial settings. It is usually formulated as a bait or gel for easy application, and has a relatively low toxicity to mammals, including humans, making it a safe and effective option for controlling insect infestations. However, it is important to use hydramethylnon products according to the label instructions to minimize any potential risks to non-target organisms.

Upstream product

• 54356-22-8 ((S)-2-hydroxymethyl-pyrrolidin-1-yl)-acetic acid tert-butyl ester 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Relevant articles and documents

Insertion of an aspartic acid moiety into cyclic pseudopeptides: Synthesis and biological characterization of potent antagonists for the human tachykinin NK-2 receptor

A new series of monocyclic pseudopeptide tachykinin NK-2 receptor antagonists has been derived from the lead compound MEN11558. A synthesis for these molecules sharing the same intermediate was designed and performed. The replacement of the succinic moiety with an aspartic acid and the functionalization of its amino group with a wide variety of substituents led to very potent and selective NK-2 antagonists. Best results were obtained through the insertion in position 12 of an amino group with R configuration, linked by a short spacer to a saturated nitrogen heterocycle (morpholine, piperidine, or piperazine). The study led to compounds 54 and 57, endowed with high in vivo potency at very low doses and long duration of action in animal models of bronchoconstriction. In particular 54 and 57 completely inhibited NK-2 agonist induced bronchoconstriction in guinea pig after intratracheal administration at subnanomolar doses (ED50 = 0.27 nmol/kg and 0.15 nmol/kg, respectively).