155701-61-4

Basic information

• Product Name: 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid
• Synonyms: 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid;GW-5638
• CAS NO: 155701-61-4
• Molecular Formula: C₂₅H₂₂O₂
• Molecular Weight: 354.44
• Mol File: 155701-61-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 508.2°Cat760mmHg
• Flash Point: 388.1°C
• Appearance: /
• Density: 1.139g/cm³
• Vapor Pressure: 3.75E-11mmHg at 25°C
• Refractive Index: 1.639
• PKA: 4.53±0.10(Predicted)
• CAS DataBase Reference: 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid(155701-61-4)
• EPA Substance Registry System: 3-(4-(1,2-diphenylbut-1-enyl)phenyl)acrylic acid(155701-61-4)

Safety Data

• Hazardous Substances Data: 155701-61-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C25H22O2/c1-2-23(20-9-5-3-6-10-20)25(21-11-7-4-8-12-21)22-16-13-19(14-17-22)15-18-24(26)27/h3-18H,2H2,1H3,(H,26,27)/b18-15+,25-23-

Upstream product

• 96212-86-1 (Z)-(1-bromobut-1-ene-1,2-diyl)dibenzene 
• 87199-17-5 4-formylphenylboronic acid, 
• 5927-18-4 trimethyl phosphonoacetate 
• 155701-60-3 (Z)-1,2-Diphenyl-1-(4-formylphenyl)-1-butene 

Relevant articles and documents

Treatment of skeletal disorders

This invention relates to methods for treating bone loss in a mammal by administering to the mammal a therapeutically effective amount of leptin or a leptin mimetic. This invention also relates to methods for treating bone fracture, enhancing bone healing following facial reconstruction, maxillary reconstruction or madibular reconstruction, enhancing long bone extension, enhancing the healing rate of a bone graft, enhancing prosthetic growth and inducing vertebral synostosis by administering a therapeutically effective amount of leptin or a leptin mimetic. This invention further relates to methods and compositions comprising leptin or a leptin mimetic and estrogen, a selective estrogen receptor modulator or a bisphonate for treating the above-recited diseases and conditions.

Treatment of skeletal disorders

This invention relates to methods for treating bone loss in a mammal by administering to the mammal a therapeutically effective amount of leptin or a leptin mimetic. This invention also relates to methods for treating bone fracture, enhancing bone healing following facial reconstruction, maxillary reconstruction or madibular reconstruction, enhancing long bone extension, enhancing the healing rate of a bone graft, enhancing prosthetic growth and inducing vertebral synostosis by administering a therapeutically effective amount of leptin or a leptin mimetic. This invention further relates to methods and compositions comprising leptin or a leptin mimetic and estrogen, a selective estrogen receptor modulator or a bisphonate for treating the above-recited diseases and conditions.

3-acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats

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