155730-92-0

Basic information

• Product Name: S-2E
• Synonyms: Benzoic acid,4-[[1-[4-(1,1-dimethylethyl)phenyl]-5-oxo-3-pyrrolidinyl]methoxy]-, (S)-;S 2E;4-{[(3S)-1-(4-tert-Butylphenyl)-5-oxopyrrolidin-3-yl]methoxy}benzoic acid
• CAS NO: 155730-92-0
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.443
• Mol File: 155730-92-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 599.089 °C at 760 mmHg
• Flash Point: 316.118 °C
• Appearance: white/powder
• Density: 1.189 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: −20°C
• Solubility: DMSO: 11 mg/mL
• CAS DataBase Reference: S-2E(CAS DataBase Reference)
• NIST Chemistry Reference: S-2E(155730-92-0)
• EPA Substance Registry System: S-2E(155730-92-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 155730-92-0(Hazardous Substances Data)

Usage

Uses

S-2E may be used in cell signaling studies.

Biochem/physiol Actions

HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.

InChI:InChI=1/C22H25NO4/c1-22(2,3)17-6-8-18(9-7-17)23-13-15(12-20(23)24)14-27-19-10-4-16(5-11-19)21(25)26/h4-11,15H,12-14H2,1-3H3,(H,25,26)/t15-/m0/s1

Upstream product

• 158898-09-0 (S)-N-[α-methyl(4-methyl)benzyl]-(S)-[1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4-yl]carboxamide 
• 155730-88-4 (S)-(+)-[1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4-yl]methyl methanesulfonate 
• 159098-82-5 (S)-(+)-1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4-carboxylic acid 
• 155730-85-1 (S)-(-)-1-(4-tert-butylphenyl)-4-hydroxymethyl-2-oxo-pyrrolidine 
• 155730-90-8 (S)-(+)-methyl 4-{[1-(4-tert-butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxy}benzoate 
• 133747-84-9 methyl 4-<1-(4-t-butylphenyl)-2-oxo-pyrrolidin-4-yl>-methyloxybenzoate 
• 133747-81-6 (+/-)-1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4-carboxylic acid 

Relevant articles and documents

Synthesis of the optical isomers of 4-[1-(4-tert-butylphenyl)-2- oxopyrrolidine-4-yl]methyloxybenzoic acid (S-2) and their biological evaluation as antilipidemic agent

The enantiomers of (±)-4-[1-(4-tert-butylphenyl)-2-oxo-pyrrolidine-4- yl]methyloxybenzoic acid (S-2), a new antilipidemic agent having dual action on the plasma triglyceride (TG) and cholesterol (Cho) lowering effects, were prepared via separation by Chir